GUARDIAN (NCT04884802) Sub-study, Phenylephrine v. Norepinephrine

Status Enrolling by invitation

Clinical Trial Summary

Some patients participating in the underlying GUARDIAN trial (NCT04884802) will be additionally randomized to norepinephrine or phenylephrine infusion to maintain the designated target intraoperative mean arterial pressure.

Clinical Trial Description

Patients participating in the underlying GUARDIAN trial (NCT04884802) will be randomized to: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management (routine pressure management). Patients participating in this sub-study will be additionally randomized to norepinephrine or phenylephrine infusion to maintain the designated target intraoperative mean arterial pressure. ;

Study Design

Related Conditions & MeSH terms

Blood Pressure

Clinical Trial Details

NCT number	NCT04934748
Study type	Interventional
Source	The Cleveland Clinic
Contact
Status	Enrolling by invitation
Phase	Phase 4
Start date	July 15, 2021
Completion date	July 2025

View Details

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