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NCT04844255 Clinical Trial

Acute Salt Sensitivity of Blood Pressure

Blood Pressure Clinical Trial

— AcuteSS  

Official title:
HIV Integrated Personalized Care Approach to the Prevention, Diagnosis, and Control of Salt-sensitive Hypertension: The HIPO CAP DICTSH STUDY

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04844255
Other study ID # PACTR202102852000433
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date December 1, 2020
Est. completion date February 28, 2021

Study information
Verified date April 2021
Source Mulungushi University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Dietary salt raises blood pressure in certain individuals immediately after ingestion (acute salt sensitivity; ASS) while not affecting others. It is hypothesized that ASS is a risk factor for hypertension. However, no thresholds or diagnostic guideline is available for ASS. This study is the first aim in the main study (HIPO CAP DITSH Study) aimed at determining the threshold or blood pressure cut-offs for ASS upon ingesting dietary salt.

Recruitment information / eligibility
Status Completed
Enrollment 132
Est. completion date February 28, 2021
Est. primary completion date February 28, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Adults aged 18 years and above. Normotensive. If Hypertensive (should be off antihypertensive medication at least 2 weeks prior to the study) Exclusion Criteria: - diabetes patients, ill participants

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• dietary salt
2 grams of dietary salt

Locations
Country Name City State
Zambia Livingstone Central Hospital Livingstone Southern

Sponsors (2)
Lead Sponsor Collaborator
Mulungushi University University of Zambia

Country where clinical trial is conducted

Zambia, 

Outcome
Type Measure Description Time frame Safety issue
Primary Acute salt sensitivity Mean arterial pressure change of 10 mmHg 160 minutes
Secondary Diastolic blood pressure change Diastolic blood pressure change of equal to or more than 10 mmHg 160 minutes
Secondary Systolic blood pressure change Systolic blood pressure change of equal to or more than 20 mmHg 160 minutes
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