Renal Physiology During Continuous Renal Replacement Therapy

Status Recruiting

Clinical Trial Summary

Approximately 50% of patients in the intensive care unit (ICU) develop acute kidney injury (AKI) and more than 10% need dialysis. There is no treatment for AKI. Care is aiming for optimization of circulation and blood flow to the kidneys and avoiding nephrotoxic agents. There is conflicting data concerning whether early or late dialysis is harmful for the kidneys. No one has examined the physiological changes in the kidney when starting dialysis and which blood pressure that leads to most optimal physiological conditions for the kidneys during dialysis. In this descriptive study of 20 ICU patients suffering from AKI we aim to investigate renal physiology when starting continuous renal replacement therapy (CRRT) and also at different target blood pressures using retrograde renal vein thermodilution technique. In parallel we will also investigate and validate this invasive method with contrast enhanced ultrasound of the kidneys.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04114747
Study type	Interventional
Source	Sahlgrenska University Hospital, Sweden
Contact	Kristina Svennerholm, MD PhD
Phone	+46313429336
Email	kristina.svennerholm@vgregion.se
Status	Recruiting
Phase	N/A
Start date	November 20, 2020
Completion date	December 31, 2025

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