Blood Pressure Clinical Trial
Official title:
Newer vs Older Antihypertensive Agents in African Hypertensive Patients Trial
The purpose of this study is to compare the blood pressure lowering efficacy of a treatment regimen based on a dihydropyridine calcium-channel blocker combined with an angiotensin II type-1 receptor blocker with the recommended treatment regimen based on a low-dose thiazide diuretic combined with a beta-blocker.
Primary objective:
Sitting systolic blood pressure (average of three readings) will be the primary outcome
variable.
Secondary
1. To compare the time interval between the two treatment groups, which after
randomisation will be required, to reach and maintain the target defined as a blood
pressure below 140 mm Hg systolic and 90 mm Hg diastolic;
2. To compare the duration of follow-up, during which a steady blood pressure control will
be achieved;
3. To evaluate the incidence of adverse events, symptoms, biochemical abnormalities and
ECG changes in the two treatment groups;
4. To assess the adherence to antihypertensive treatment as well as the rate of drop-outs
in both treatment arms during a six-month period.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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