Study of Atenolol Influence on Blood Pressure During Resistance Exercise

Blood Pressure Clinical Trial

Official title:

Blood Pressure Response During Resistance Exercise in Hypertensives: Influence of Beta-blockers

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01030016
• Other study ID #: FAPESP-06/06356-8
• Status: Completed
• Phase: Phase 4
• First received: December 8, 2009
• Last updated: December 14, 2009
• Start date: May 2007
• Est. completion date: May 2009

Study information

• Verified date: May 2009
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

The study was designed to investigate if atenolol is able to blunt blood pressure increase during resistance exercise in hypertensive subjects.

Description:

The study compared intra-arterial blood pressure responses during leg-extension resistance exercise performed to fatigue at 40, 80 and 100% of 1 RM in hypertensive patients receiving placebo (first) and atenolol (second) on a single blind manner.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: May 2009
• Est. primary completion date: May 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 30 Years to 60 Years

Eligibility

Inclusion Criteria:

• hypertension with blood pressure levels below 160/105 mmHg under placebo.

• age between 30 and 60 years

• nonobese

Exclusion Criteria:

• target organ lesion

• cardiovascular risk factor

• cardiovascular disease

• physically active

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Supportive Care

Related Conditions & MeSH terms

• Blood Pressure
• Exercise

Intervention

Drug:
• atenolol
25 mg/day, twice a day for 6 weeks

Locations

Country	Name	City	State
Brazil	University of São Paulo	São Paulo

Sponsors (2)

Lead Sponsor	Collaborator
University of Sao Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	blood pressure during resistance exercise		6 weeks	Yes