Blood Glucose, High Clinical Trial
Official title:
Nitroglycerin Infusion During Rewarming in Cardiac Surgery and Its Effects on Tissue Perfusion and Coagulation
Verified date | October 2020 |
Source | Tri-Service General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Hypothermic cardiopulmonary bypass results in peripheral vasoconstriction and heparin trapping. Hypoperfusion and ischemic-reperfusion injury are associated with systemic inflammatory response, while insufficient and delayed neutralization of heparin by protamine may contribute to more blood loss during rewarming stage. Nitroglycerin infusion, an NO-related vasodilator, is an established and effective treatment for unstable angina, myocardial infarction, congestive heart failure, and perioperative hemodynamic management for cardiac surgery. Therefore, we hypothesize that nitroglycerin infusion during rewarming corrects systemic ischemic stress and facilitates heparin neutralization in cardiac surgery.
Status | Completed |
Enrollment | 80 |
Est. completion date | June 8, 2017 |
Est. primary completion date | June 8, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 85 Years |
Eligibility | Inclusion Criteria: - elective cardiac surgery Exclusion Criteria: - heart failure, respiratory failure, asthma attack, uremia, normothermic bypass. |
Country | Name | City | State |
---|---|---|---|
Taiwan | Tri-Service General Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
Tri-Service General Hospital |
Taiwan,
Masoumi G, Pour EH, Sadeghpour A, Ziayeefard M, Alavi M, Anbardan SJ, Shirani S. Effect of different dosages of nitroglycerin infusion on arterial blood gas tensions in patients undergoing on- pump coronary artery bypass graft surgery. J Res Med Sci. 2012 Feb;17(2):123-7. — View Citation
Piquette D, Deschamps A, Bélisle S, Pellerin M, Levesque S, Tardif JC, Denault AY. Effect of intravenous nitroglycerin on cerebral saturation in high-risk cardiac surgery. Can J Anaesth. 2007 Sep;54(9):718-27. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Cardiac Index, Before Start of CPB | Cardiac Index, L/min/m2, Before Start of CPB | Before Start of CPB | |
Other | Cardiac Index, Cessation of CPB | Cardiac Index, L/min/m2, Cessation of CPB | Cessation of CPB | |
Other | Cardiac Index, After Protamine Administration | Cardiac Index, L/min/m2, After Protamine Administration | After Protamine Administration | |
Other | Cardiac Index, Upon Arrival at ICU | Cardiac Index, L/min/m2, Upon Arrival at ICU | Upon Arrival at ICU | |
Other | Cerebral Oximetry, Before Start of CPB, Left Forehead | Absolute Value of Cerebral Oximetry, %, Before Start of CPB, Left Forehead | Before Start of CPB | |
Other | Cerebral Oximetry, Before Start of CPB, Right Forehead | Absolute Value of Cerebral Oximetry, %, Before Start of CPB, Right Forehead | Before Start of CPB | |
Other | Cerebral Oximetry, Beginning Rewarming, Left Forehead | Absolute Value of Cerebral Oximetry, %, Beginning Rewarming, Left Forehead | Beginning Rewarming | |
Other | Cerebral Oximetry, Beginning Rewarming, Right Forehead | Absolute Value of Cerebral Oximetry, %, Beginning Rewarming, Right Forehead | Beginning Rewarming | |
Other | Cerebral Oximetry, Release of Aortic Clamp, Left Forehead | Absolute Value of Cerebral Oximetry, %, Release of Aortic Clamp, Left Forehead | Release of Aortic Clamp | |
Other | Cerebral Oximetry, Release of Aortic Clamp, Right Forehead | Absolute Value of Cerebral Oximetry, %, Release of Aortic Clamp, Right Forehead | Release of Aortic Clamp | |
Other | Cerebral Oximetry, Cessation of CPB, Left Forehead | Absolute Value of Cerebral Oximetry, %, Cessation of CPB, Left Forehead | Cessation of CPB | |
Other | Cerebral Oximetry, Cessation of CPB, Right Forehead | Absolute Value of Cerebral Oximetry, %, Cessation of CPB, Right Forehead | Cessation of CPB | |
Other | Cerebral Oximetry, After Protamine Administration, Left Forehead | Absolute Value of Cerebral Oximetry, %, After Protamine Administration, Left Forehead | After Protamine Administration | |
Other | Cerebral Oximetry, After Protamine Administration, Right Forehead | Absolute Value of Cerebral Oximetry, %, After Protamine Administration, Right Forehead | After Protamine Administration | |
Primary | Plasma Lactate Level, Before Incision | Plasma Lactate Level, mmol/L, Before Incision | Before Incision | |
Primary | Plasma Lactate Level, Before Start of CPB | Plasma Lactate Level, mmol/L, Before Start of CPB | Before Start of CPB | |
Primary | Plasma Lactate Level, Release of Aortic Clamp | Plasma Lactate Level, mmol/L, Release of Aortic Clamp | Release of Aortic Clamp | |
Primary | Plasma Lactate Level, After Protamine Administration | Plasma Lactate Level, mmol/L, After Cessation of CPB and Protamine Administration | After Protamine Administration | |
Primary | Plasma Lactate Level, Upon Arrival at ICU | Plasma Lactate Level, mmol/L, Upon Arrival at ICU | Upon Arrival at ICU | |
Primary | Plasma Glucose Level, Before Incision | Plasma Glucose Level, mg/dL, Before Incision | Before Incision | |
Primary | Plasma Glucose Level, Before Start of CPB | Plasma Glucose Level, mg/dL, Before Start of CPB | Before Start of CPB | |
Primary | Plasma Glucose Level, Release of Aortic Clamp | Plasma Glucose Level, mg/dL, Release of Aortic Clamp | Release of Aortic Clamp | |
Primary | Plasma Glucose Level, After Protamine Administration | Plasma Glucose Level, mg/dL, After Cessation of CPB and Protamine Administration | After Protamine Administration | |
Primary | Plasma Glucose Level, Upon Arrival at ICU | Plasma Glucose Level, mg/dL, Upon Arrival at ICU | Upon Arrival at ICU | |
Primary | Mean Arterial Blood Pressure = 40 mmHg After Initiation of NTG Infusion | Mean Arterial Blood Pressure = 40 mmHg After Initiation of NTG Infusion During Rewarming of Cardiopulmonary Bypass | After Initiation of NTG infusion During Rewarming | |
Secondary | Activated Coagulation Time, Before Start of CPB | Activated Coagulation Time, sec, Before Start of CPB | Before Start of CPB | |
Secondary | Activated Coagulation Time, After Protamine Administration | Activated Coagulation Time, sec, After Cessation of CPB and Protamine Administration | After Protamine Administration | |
Secondary | Post-op Dopamine Infusion | Infusion Rate of Dopamine, mcg/kg/min, Upon Arrival at ICU | Upon Arrival at ICU | |
Secondary | Time to Extubation | Time from Arrival at ICU to Extubation, hour | Arrival at ICU and Extubation | |
Secondary | Length of ICU Stay | Time from Arrival at ICU to Leaving ICU, day | Arrival at ICU and Leaving ICU |
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