Muscle Weakness Clinical Trial
Official title:
Neuromodulation for Prevention of Intensive Care Unit Acquired Weakness and Post Intensive Care Syndrome
Post-intensive care syndrome (PICS) encompasses persistent physical, cognitive, and psychiatric symptoms following ICU discharge, commonly triggered by serious conditions such as respiratory failure, sepsis, and mechanical ventilation. PICS prevalence is reported to be as high as 84% up to 12 months in patients with at least 2 days spent in the ICU or with mechanical ventilatory support. As a consequence, many patients do not return to they former level of function for weeks, months and even years. Muscular affection manifested by muscle weakness is particularly seen and is provoked by a combination of damage to the nerves or directly the muscles fibers. This affection is referred to as CU-Acquired Weakness (ICUAW). One third of the time, lower extremities are affected, often due to prolonged immobilization or sedation. Evidence suggests that early mobilization reduces the incidence of ICUAW at discharge and improves the number of patients able of stand. However achieving this early intervention is not always feasible due to time or personnel constraints. The purpose of the study is to examine the effectiveness of lower extremity neuromodulation for prevention of muscle deconditioning in patients admitted to the ICU.
The purpose of the study is to examine feasibility and acceptability of lower extremity neuromodulation in patients at risk of ICUAW. This is a proof Randomized controlled trial (RCT) study for prevention. Eligible participants will be recruited from Baylor St Luke's Medical Center (Houston, Texas). Participants will be randomized to intervention group (IG) or control group (CG). The entire cohort will receive daily neuromodulation in the lower extremity (Gastrocnemius muscle, Achilles tendon) up to 1 hour. The therapy will be provided with a neuromodulation device (Tennant Biomodulator PRO®, AVAZZIA, Inc.) that works on high voltage alternative pulsed current. The device will be functional for the IG and non-functional for the CG. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05543980 -
Leg Heat Therapy in Elderly Individuals
|
Phase 2 | |
Enrolling by invitation |
NCT03297632 -
Improving Muscle Strength, Mass and Physical Function in Older Adults
|
N/A | |
Completed |
NCT04207359 -
Effects of Creatine Supplementation in Breast Cancer Survivors
|
N/A | |
Completed |
NCT06216015 -
Exercise Training and Kidney Transplantation
|
N/A | |
Completed |
NCT04076982 -
Effect of Supplementary Dietary Protein (21g Per Day) on Lean Mass and Strength in Sedentary, Adult Vegetarians
|
N/A | |
Not yet recruiting |
NCT03662555 -
Effect of Neuromuscular Electrical Stimulation Combined With Blood Flow Restriction on Muscular and Cardiovascular Function
|
N/A | |
Completed |
NCT02530723 -
Functional Changes and Power Training in Older Women.
|
N/A | |
Completed |
NCT01743495 -
CAPABLE for Frail Dually Eligible Older Adults
|
N/A | |
Completed |
NCT01704976 -
SR-WBV Training for Frail Elderly in the Skilling up Stage
|
N/A | |
Completed |
NCT00183040 -
HORMA: Hormonal Regulators of Muscle and Metabolism in Aging
|
Phase 2 | |
Enrolling by invitation |
NCT06432062 -
Investigation the Effect of Rectus Abdominis and Erector Spinae Muscle Fatigue on the Viscoelastic Properties of Thoracolumbal Fascia
|
||
Recruiting |
NCT05073224 -
Muscle Function After Childbirth
|
N/A | |
Completed |
NCT04956705 -
Vitamin D and Calcium Supplementation at Danish Nursing Homes
|
N/A | |
Recruiting |
NCT03810768 -
Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
|
||
Completed |
NCT00060970 -
Evaluating Muscle Function After Ankle Surgery
|
N/A | |
Completed |
NCT04546048 -
The Early Strength Training Program in Post-transplant Liver Cases
|
N/A | |
Completed |
NCT03628365 -
Can Beta-Hydroxy-beta-Methylbutyrate Supplementation Counteract Muscle Catabolism in Critically Ill Patients?
|
N/A | |
Completed |
NCT05056298 -
Effect of Insole Added to Exercise in Patients With Bilateral Flexible Flatfoot
|
N/A | |
Completed |
NCT02739464 -
Effect of In-Patient Exercise Training on Length of Hospitalization in Burned Patients
|
N/A | |
Completed |
NCT05497960 -
Vivo Prediabetes Study: Online, Live, and Interactive Strength Training for Older Adults With Prediabetes
|
N/A |