Inflammation Clinical Trial
Official title:
Coagulation, Inflammation and Cerebral Embolism Using a Rheoparin-coated Tubing System for Minimized Extracorporeal Circulation (MECC): Differences to the Conventional MECC System
In this study, the investigators would like to compare a heparin-coated tubing system for minimized extracorporeal circulation (MECC) with the conventional tubing system for MECC, which does not contain heparin coating. The MECC system has been used since 14 years in the investigators' hospital as an extracorporeal system to support circulation and provide oxygen to the tissues during coronary artery bypass grafting. Until today, the investigators performed more than 5000 MECC procedures in their department.
Background
The investigators would like to investigate a new composition of their MECC system in
patients receiving coronary artery bypass surgery. Normally, the MECC system induces
complement system activation and coagulation cascade, which could have a negative impact on
postoperative outcome. A tubing system containing heparin (rheoparin) could contribute to a
better biocompatibility in terms of a diminished activation of inflammatory reactions and a
reduction of cerebral embolic load, which is a regular issue during extracorporeal
circulation due to formation of solid and gaseous microemboli in the tubing system.
Objective
The aim is to investigate biocompatibility (coagulation, inflammation) and influence on
cerebral embolic load of the rheoparin-coated MECC system and to compare the results with the
current MECC system containing a rheoparin-free tubing system.
Methods
Patients undergoing elective coronary artery surgery are randomized to receive extracorporeal
circulation using the MECC system with or without rheoparin coating. All procedures are
performed according to the institutional standards.
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