Liver Cirrhosis Clinical Trial
Official title:
Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant
A point-of-care bleeding management protocol based on global viscoelastic test (thromboelastometry) can change the amount of blood products used during orthotopic liver transplant.
Patients with liver disease frequently acquire a complex disorder of hemostasis secondary to
their disease.
The fundamental key to the management of coagulopathy of cirrhotic patient is the knowledge
that hepatic dysfunction results in impairment of both pro-hemostatic factors as
anti-hemostatic factors in a disproportionate manner which can lead to a clinical picture of
both bleeding and thrombosis.
Routine tests of coagulation as prothrombin time (PT, INR) and activated partial
thromboplastin time (APTT) although prolonged in cirrhotic patients cannot predict bleeding.
Global viscoelastic test of whole blood (TEG / ROTEM) produce a dynamic composite image of
the entire coagulation process and have the potential to provide clinically relevant
information in patients with liver disease allowing rational use of blood products during
liver transplantation.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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