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Clinical Trial Summary

This study is designed as a randomized, double-blind, sham-controlled, single-center research study in which healthy adults will be randomized 1:1 into one of two experimental groups, to receive transcutaneous auricular vagus nerve stimulation (taVNS) targeting either the auricular branch of the vagus nerve (ABVN) or tAN, which targets the ABVN and the auriculotemporal nerve (ATN): 1. Group 1: Sham taVNS followed by active taVNS 2. Group 2: Sham tAN followed by active tAN Participants will receive 30 minutes of sham stimulation (taVNS or tAN), followed by active stimulation (taVNS or tAN). Blood biomarkers (local and systemic) will be measured before and at several timepoints after stimulation to measure the molecular and cellular effects of the device.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05977946
Study type Interventional
Source Spark Biomedical, Inc.
Contact Maaryj Ahmad
Phone (516) 562-1505
Email mahmad11@northwell.edu
Status Recruiting
Phase N/A
Start date October 31, 2023
Completion date June 2024

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