Pancreatic Carcinoma Clinical Trial
Official title:
Combined Stent Insertion and High-intensity Focused Ultrasound Ablation for Pancreatic Carcinoma With Biliary Obstruction
The purpose of this study is to compare the clinical effectiveness and long-term outcomes between patients with pancreatic carcinoma and biliary obstruction who are treated by stent insertion with or without high-intensity focused ultrasound ablation.
Distal malignant biliary obstruction is a common problem in patients with pancreatic
carcinoma. In unresectable pancreatic carcinomas, percutaneous stent placement has been
pivotal in providing relief from obstructive jaundice, improving the quality of life, and
allowing the maintenance of anticancer treatment.
Venous chemotherapy, transcatheter arterial chemoembolization, or radiotherapy have been used
to prolong stent patency and survival after stent insertion for patients with pancreatic
carcinoma and biliary obstruction. High-intensity focused ultrasound ablation is a
noninvasive and atoxic treatment of malignant tumor using focused ultrasound energy from an
extracorporeal source that is targeted within the body resulting in thermally induced
necrosis and apoptosis.
The purpose of this study is to compare the clinical effectiveness and long-term outcomes
between patients with pancreatic carcinoma and biliary obstruction who are treated by stent
insertion with or without high-intensity focused ultrasound ablation.
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