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Bile Acid Malabsorption clinical trials

View clinical trials related to Bile Acid Malabsorption.

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NCT ID: NCT05245357 Recruiting - Inflammation Clinical Trials

Impact of Foods on Bile Acids, Metabolites, and Inflammation

Start date: February 24, 2022
Phase: N/A
Study type: Interventional

Dietary incorporation of pulse crops may be an effective way to lower unhealthy elevations in serum bile acids. These elevations play a direct role in promoting obesity-related diseases estimated to be present in about one third of the US adult population, including non-alcoholic fatty liver disease and type 2 diabetes. The overarching hypothesis for this study is that pulse consumption increases bile acid secretion and excretion, which will decrease toxicity linked to excess accumulation of bile in the liver, improve metabolism, and lower resulting levels of bile acids in the serum. In direct alignment with the USDA-AFRI Food, Safety, Nutrition, and Health priority to address obesity and related chronic disease with increased fruit and vegetable consumption and also with the American Pulse Association call to investigate the impact of regular pulse consumption on human physical well- being, the long-term research goal of this study is to establish effective and practical therapeutic strategies utilizing dietary incorporation of pulse crops to prevent or reverse obesity driven diseases. The specific objectives in this proposal are to: 1. determine the impact of acute lentil ingestion on serum postprandial bile acid responses and composition in a human cohort with obesity, and 2. determine the impact of daily lentil consumption for 12 weeks on serum fasting and postprandial bile acid concentrations and composition in an overweight or obese cohort with elevated postprandial triglycerides. This proposal is being submitted in response to the American Pulse Association commodity board sponsored topic of investigating the impact pulse crop consumption on health.

NCT ID: NCT05130047 Completed - Clinical trials for Irritable Bowel Syndrome With Diarrhea

Aldafermin (NGM282) for Chronic Diarrhea Due to Bile Acid Malabsorption (BAM)

Start date: December 1, 2021
Phase: Phase 2
Study type: Interventional

This single-center, randomized, double-blind, placebo-controlled study is designed to compare effects of aldafermin, (NGM282), 1 mg, and placebo given daily by subcutaneous injection on bowel functions and hepatic synthesis and fecal excretion of bile acids in patients with diarrhea associated with bile acid malabsorption (BAM).

NCT ID: NCT03955575 Completed - Clinical trials for Bile Acid Malabsorption

Treatment of Bile Acid Malabsorption With Liraglutide

BAM-LIRA
Start date: March 7, 2019
Phase: Phase 4
Study type: Interventional

Comparing the effect of Liraglutide on bile acid malabsorption, with colesevelam

NCT ID: NCT03876717 Completed - Chronic Diarrhea Clinical Trials

Effect of the Sequestrant Colesevelam in Bile Acid Diarrhoea

SINBAD
Start date: October 25, 2018
Phase: Phase 4
Study type: Interventional

Bile acid diarrhoea is a chronic disease that impairs quality of life. One in 100 has the condition and many suffer from the disease without knowing. The current test is called SeHCAT and is expensive and time-consuming and is unavailable in many places, including the US. The disease is often misdiagnosed as irritable bowel syndrome and estimated one third of patients with irritable bowel syndrome of the mixed type and the diarrhoea predominant type suffer from bile acid diarrhoea without knowing. A blood test called 7α-hydroxy-4-cholestene-3-one (C4) could make it much easier to diagnose bile acid diarrhoea. To establish the new test, the results of both C4 and SeHCAT are compared with the treatment effect of the drug called colesevelam. We invite patients who are referred for the SeHCAT test to participate in the trial. The SeHCAT test takes two days that are one week apart. The study patients register stool habits with a diary in the week between the SeHCAT visits. Based on the diary results, we screen for eligibility; e.g. a certain degree/severity of diarrhoea is required for participation. We treat eligible study patients (i.e those with diarrhoea) with either colesevelam or placebo (medicine without effect) that is randomly assigned. 170 study patients need to complete the treatment. We aim to validate (ie. compare) both the C4-test and the SeHCAT test with the colesevelam treatment response as the reference.

NCT ID: NCT03270085 Completed - Clinical trials for Irritable Bowel Syndrome With Diarrhea

Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid Malabsorption

Start date: December 7, 2017
Phase: Phase 2
Study type: Interventional

To compare with a randomized trial (n=15 per treatment group), effects of colesevelam and placebo treatment, on colonic transit, bowel functions, permeability and tight junction expression in rectosigmoid mucosa of IBS-D with Bile Acid Malabsorption.

NCT ID: NCT03168555 Completed - Cholelithiasis Clinical Trials

Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy

BACH
Start date: June 22, 2017
Phase: Phase 4
Study type: Interventional

Investigate serial plasma samples of fibroblast growth factor 19 (FGF19) after oral stimulation with chenodeoxycholic acid in the same subjects before and after elective cholecystectomy

NCT ID: NCT03059537 Completed - Clinical trials for Bile Acid Malabsorption

Validation of Stimulated ∆FGF19 for Diagnosing Bile Acid Diarrhoea

VABAD
Start date: March 13, 2017
Phase: Phase 4
Study type: Interventional

This study aims to validate a possible diagnostic test for bile acid diarrhoea prospectively compared to the SeHCAT scintigraphy. Fasting participants are given a standard meal and 1,250 mg chenodeoxycholic acid. The investigators measure fasting FGF19, bile acids species including 7-alpha-CHO and serial blood samples after the stimulation.

NCT ID: NCT02628626 Completed - Fecal Incontinence Clinical Trials

A Study of Colesevelam in Fecal Incontinence

Start date: November 2015
Phase: Phase 3
Study type: Interventional

Compare the effects of a combination of colesevelam and clonidine to placebo on bowel symptoms in patients with urge or combined type of FI.

NCT ID: NCT02078856 Completed - Clinical trials for Bile Acid Malabsorption

Double-blind, Randomised Study of A3384 in BAM/BAD

Start date: March 2014
Phase: Phase 2
Study type: Interventional

The purpose of this trial is to determine the efficacy and safety of A3384 administered to patients with Bile Acid Malabsorption (BAM)/Bile Acid Diarrhoea (BAD).

NCT ID: NCT01203254 Terminated - Crohns Disease Clinical Trials

Colesevelam for the Treatment of Bile Acid Malabsorption in Patients With Crohn's Disease

COBAM
Start date: October 2010
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the efficacy of cholestagel to reduce the frequency of soft and liquid stools per day in patients with CD in clinical remission with symptoms of BAM and to assess the improvement in stool consistency and quality of life in these patients and to assess the safety of cholestagel.