Thoracic Aortic Aneurysm Clinical Trial
Official title:
The Effect of Losartan Treatment on Matrix Metalloproteinase Levels and Outcomes in Bicuspid Aortic Valve Patients
The specific aims of this study are to:
- Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in
individuals with bicuspid aortic valve and ascending aortic or aortic sinus
measurements >40mm.
- Assess the effect on MMP levels during treatment with losartan, an angiotensin II
receptor blocking agent.
- In the setting of losartan therapy for one year, evaluate the response of MMP levels in
these patients, and clinical outcomes including effects on aortic growth rate
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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