Basic Science Clinical Trial
Official title:
Influence of Oxytocin on Approach-avoidance Tendencies to Social and Non-social Stimuli
Verified date | June 2020 |
Source | KU Leuven |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In this study, a randomized, placebo-controlled between-subject design is adopted to investigate the effect of a single-dose of intranasally administered OT on approach-avoidance related motivational tendencies during the processing of a series of social and non-social, positively and negatively valenced stimuli. To obtain a behavioral measure of approach-avoidance tendencies, participants will be able to control the viewing time of the presented stimuli, by pressing 'up' or 'down' on a keyboard. During stimulus presentation neurophysiological recordings will be performed to obtain a neural measure of approach-avoidance motivational tendencies, based on electroencephalographic recordings (EEG: frontal alpha asymmetry). Also assessments of autonomic arousal, based on skin conductance recordings will be collected.
Status | Completed |
Enrollment | 64 |
Est. completion date | January 30, 2020 |
Est. primary completion date | January 30, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - right-handed - male - age between 18 and 35 - Normal or adjusted-to-normal vision (with lenses only) - Dutch as mother tongue Exclusion Criteria: - female - age below 18 or above 35 - neurological or psychiatric condition (e.g. epilepsy, stroke, concussion), (e.g. anxiety disorder, depression) - use of psychotropic medication (e.g. anxiolytics, antidepressants) |
Country | Name | City | State |
---|---|---|---|
Belgium | KU Leuven | Leuven |
Lead Sponsor | Collaborator |
---|---|
KU Leuven |
Belgium,
Harari-Dahan O, Bernstein A. A general approach-avoidance hypothesis of oxytocin: accounting for social and non-social effects of oxytocin. Neurosci Biobehav Rev. 2014 Nov;47:506-19. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in EEG frontal alpha asymmetry after nasal spray administration | The influence of oxytocin administration on EEG frontal alpha asymmetry | Average over trials, baseline and approximately 30 minutes after nasal spray administration | |
Primary | Change in behavioral approach-avoidance (number of up or down key presses, prolonging or shortening the viewing time towards presented stimuli) | During the presentation of a series of stimuli, participants will be able to prolong or shorten the viewing time towards the presented stimuli, by pressing an 'up' or 'down' key on a keyboard. The number of up versus down key-presses will be taken as a measure of behavioral approach-avoidance. The influence of oxytocin administration on the number of up or down key presses will be assessed. |
Average over trials, baseline and approximately 30 minutes after nasal spray administration | |
Primary | Change in skin conductance (type of electrodermal recording) after nasal spray administration | The influence of oxytocin adminstration on skin conductance | Average over trials, baseline and approximately 30 minutes after nasal spray administration |
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