The Effects of Buprenorphine on Responses to Verbal Tasks

Status Completed

Clinical Trial Summary

In this study, the investigators will examine the effects of buprenorphine, as compared to placebo, upon physiological, subjective, and hormonal responses to a stressful speech task and a non-stressful control task in healthy adults. There is strong evidence in support of the role of endogenous opioids and opiates in mediating social behavior in humans and other animals, and particularly, in social distress. Recently it has been shown that buprenorphine, a partial mu-opioid agonist, reduces sensitivity to recognition of fearful facial expressions in humans. Here, the investigators propose to further explore the role of the opioid system in mediating stress responses in humans through the use of buprenorphine. The investigators hypothesize that buprenorphine with reduce both physiological and subjective measures of stress.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Basic Science

Clinical Trial Details

NCT number	NCT01860287
Study type	Interventional
Source	University of Chicago
Contact
Status	Completed
Phase	Early Phase 1
Start date	September 2013
Completion date	January 2017

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