A Study of Vismodegib (GDC-0449) in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma

Basal Cell Carcinoma Clinical Trial

Official title:

A Single-Arm, Open-Label, Expanded Access Study of Vismodegib (GDC-0449) in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma

Clinical Trial Details — Status: Approved for marketing

Administrative data

• NCT number: NCT01160250
• Other study ID #: SHH4811g
• Status: Approved for marketing
• Phase: Phase 4
• First received: July 8, 2010
• Last updated: August 4, 2015
• Start date: July 2010
• Est. completion date: April 2012

Study information

• Verified date: August 2015
• Source: Genentech, Inc.
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Expanded Access

Clinical Trial Summary

This is an open-label, non-comparative, multicenter, expanded access study of Vismodegib (GDC-0449) in patients with locally advanced basal cell carcinoma (BCC) or metastatic BCC (mBCC) who are otherwise without satisfactory treatment options.

Recruitment information / eligibility

• Status: Approved for marketing
• Enrollment: 0
• Est. completion date: April 2012
• Est. primary completion date: April 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• For patients with mBCC, histologic confirmation of distant BCC metastasis

• For patients with locally advanced BCC, at least one histologically confirmed lesion 10 mm or more in diameter and written confirmation from a surgical specialist that the tumor is considered inoperable or that surgery is contraindicated

• For patients with locally advanced BCC, radiotherapy must have been previously administered for locally advanced BCC, unless radiotherapy is contraindicated or inappropriate. For patients whose locally advanced BCC has been irradiated, disease must have progressed after radiation.

• Patients with Gorlin syndrome may enroll in this study but must meet the criteria for locally advanced or metastatic disease listed above

• Patients with measurable and/or non-measurable disease (as defined by RECIST) are allowed

• Adequate organ function

• For women of childbearing potential, agreement to the use of two acceptable methods of contraception, including one barrier method, during the study and for 12 months after discontinuation of Vismodegib (GDC-0449)

• For men with female partners of childbearing potential, agreement to use a latex condom, and to advise their female partner to use an additional method of contraception during the study and for 3 months after discontinuation of Vismodegib (GDC-0449)

Exclusion Criteria:

• Pregnancy or lactation

• Life expectancy < 12 weeks

• Concurrent non-protocol-specified anti-tumor therapy

• Completion of most recent anti-tumor therapy at least 21 days prior to initiation of treatment

• Uncontrolled medical illnesses such as infection requiring treatment with intravenous antibiotics

• History of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates use of an investigational drug or that might affect interpretation of the results of the study or renders the patient at high risk from treatment complications

• Unwillingness to practice effective birth control

Study Design

N/A

Related Conditions & MeSH terms

• Basal Cell Carcinoma
• Carcinoma
• Carcinoma, Basal Cell

Intervention

Drug:
• vismodegib (GDC-0449)
Oral repeating dose

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Genentech, Inc.

Country where clinical trial is conducted

United States,