Basal Cell Carcinoma Recurrence After Mohs Surgery

Status Completed

Clinical Trial Summary

Basal cell carcinoma (BCC) is the most common skin cancer in the US and can cause significant adverse effects. Mohs micrographic surgery, the treatment of choice for higher risk BCC, allows for removal of lesions with preservation of healthy tissue. Although the BCC recurrence rate post Mohs surgery is estimated at 1-2%, recent data is lacking to validate this historical measurement. Our purpose is to determine the current recurrence rate of BCC after Mohs surgery.

Clinical Trial Description

Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer in the United States, affecting nearly one million of all Americans. While BCC is rarely mortal, it has significant associated physical, psychological, and monetary costs to patients such as disfigurement and sensory loss. Individuals who have been diagnosed with at least one BCC lesion are likely to be diagnosed with more in the future. Treatment of these lesions and recurrent physician appointments can be a great inconvenience to patients, resulting in expenses to patients and loss of work and family time. The Mohs surgery technique is associated with a low recurrence rate for BCC and is preferred for higher risk tumors and for tumors in cosmetically sensitive sites on the head and neck. While recurrence rates of BCC post Mohs are 1-2% for primary basal cells, recent data is not available to validate this historical assessment. Currently, comprehensive rates of recurrence are not available because a national registry of recurrence rates for BCC and squamous cell carcinoma (SCC) does not exist. The purpose of this study is to both historically and prospectively assess current basal cell carcinoma recurrence rates in patients undergoing Mohs micrographic surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00882791
Study type	Observational
Source	Northwestern University
Contact
Status	Completed
Phase
Start date	May 2008
Completion date	May 2009

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04552990` - Use of Jet-injection in Photodynamic Therapy for Basal Cell Carcinoma	Phase 2
Completed	`NCT04229277` - Fast Track Diagnosis of Skin Cancer by Advanced Imaging	N/A
Completed	`NCT05608902` - Structural Description of Skin Biopsies With Dynamic Full-field Optical Coherence Tomography on Suspected Basal Cell Carcinoma Lesions, a Pilot Study (DOCTOBA)
Completed	`NCT05077033` - Intratumoral phIL12 GET	Phase 1
Active, not recruiting	`NCT04928222` - Placebo Microneedles in Healthy Volunteers (Part I) and Efficacy/Safety of Doxorubicin Microneedles in Basal Cell Cancer Subjects (Part II)	Phase 1/Phase 2
Recruiting	`NCT04929535` - Hydrogen Peroxide Trial to Investigate the Efficacy of 30%H2O2 as a Topical Application Before Definitive Treatment	Phase 2
Completed	`NCT02662244` - Long-pulsed 1064 nm Nd:YAG Laser Treatment of Basal Cell Carcinoma	N/A
Completed	`NCT00959647` - A Study of Vismodegib (GDC-0449) in Patients Treated With Vismodegib in a Previous Genentech-sponsored Phase I or II Cancer Study	Phase 2
Completed	`NCT00586040` - Photochemical Tissue Bonding	Phase 2
Completed	`NCT00793169` - Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery
Completed	`NCT00473343` - Metvix PDT in Participant With "High Risk" Basal Cell Carcinoma	Phase 3
Active, not recruiting	`NCT06024629` - cOCT Versus LC-OCT for Diagnosing Basal Cell Carcinoma: a Diagnostic Cohort Study
Not yet recruiting	`NCT05324202` - New Imaging Procedures and Therapeutic Approach in Basal Cell Carcinoma Management	N/A
Withdrawn	`NCT04099446` - A Non-Interventional Pilot Study to Explore the Skin Microbes in Skin Cancer
Completed	`NCT02902822` - Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo	N/A
Completed	`NCT01260987` - Fractional CO2 Laser Assisted Photodynamic Therapy	Phase 2/Phase 3
Completed	`NCT01201915` - A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449) in Operable Basal Cell Carcinoma	Phase 2
Completed	`NCT01208831` - An East Asian Study of LDE225	Phase 1
Completed	`NCT01014819` - A Clinical Trial of Dermacorder for Detecting Malignant Skin Lesions	N/A
Completed	`NCT00472043` - PDT With Metvix 160 mg/g Cream Versus PDT With Placebo Cream in Patients With Primary Nodular Basal Call Carcinoma	Phase 3