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Barrett Esophagus clinical trials

View clinical trials related to Barrett Esophagus.

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NCT ID: NCT05846971 Active, not recruiting - Esophageal Cancer Clinical Trials

Clinical Utility of Methylation-based Prognostic Assay for Barrett's Esophagus

Start date: January 26, 2021
Phase: N/A
Study type: Interventional

Capsulomics has developed a prognostic assay for patients with diagnosed Barrett's esophagus (BE). This study will measure how gastroenterologists make surveillance and treatment management decisions when presented with different clinical and prognostic assay information.

NCT ID: NCT05578677 Active, not recruiting - Barrett Esophagus Clinical Trials

Endoscopic Biopsy Techniques in Barrett's Esophagus Patients

BITE
Start date: June 23, 2021
Phase: N/A
Study type: Interventional

Barrett's esophagus (BE) is a premalignant condition of the distal esophagus, predisposing to dysplasia and esophageal adenocarcinoma. Therefore, in BE patients, current guidelines recommend endoscopic surveillance with four-quadrant biopsies every 2 centimeters of the Barrett's length. These biopsies need to be of optimal quality for adequate histopathological assessment. Larger biopsies can facilitate adequate histopathological assessment because (1) more tissue is available, (2) larger biopsies usually result in less superficial biopsies, with all mucosal layers present in the biopsy specimen, and (3) larger biopsies will ease orientation of the specimen. In a pilot study, the investigators found a median increase of nearly 30% in surface area when the biopsies were obtained by BE-expert endoscopists in comparison with non BE-expert endoscopists. A possible explanation for this difference can be biopsy method or technique. BE-expert endoscopists use the single biopsy method and turn-and-suction technique, whereas the double biopsy method and the advance-and-close technique are the more generally used biopsy techniques within non BE-expert endoscopists. The BITE study is therefore designed to identify the preferred biopsy technique and method in BE patients in order to optimise biopsy quality and histopathological assessment.

NCT ID: NCT04408105 Active, not recruiting - Clinical trials for Gastroesophageal Reflux Disease

Survey Study on Barrett's Esophagus Screening

SCREEN-BE
Start date: February 19, 2020
Phase:
Study type: Observational

The goal of this study is to optimize Barrett's Esophagus (BE) screening to reduce the incidence, morbidity, and mortality of Esophageal Adenocarcinoma (EAC).

NCT ID: NCT04151524 Active, not recruiting - Barrett Esophagus Clinical Trials

Classification of Adenocarcinoma of the Esophagogastric Junction

Start date: October 23, 2019
Phase:
Study type: Observational

The Siewert classification of oesophageal cancer is the standard approach in anatomically subdividing cancer of the lower oesohagus.

NCT ID: NCT03835663 Active, not recruiting - Gastric Cancer Clinical Trials

The Bacterial Composition of the Stomach in Reflux Disease

Start date: June 4, 2018
Phase:
Study type: Observational

Gastric and oesophageal (OG) cancer associated with poor long term outcome as overall less than 25% of patients survive for more than 5 years due to late recognition of the disease. Growing evidence suggests an important role for bacteria in OG cancer and gastro esophageal reflux disease (GORD) development. About 1 in 10 people suffer from GORD and this one of the most common conditions leading to gastric and oesophageal cancer. In GORD surgical therapy is the most successful preventing cancer but around 85% of patient experience complications afterwards. Acid suppressing medications are reducing the risk of oesophageal cancer but equally increasing the risk of gastric cancer. They also shorten patients' life expectancy and often fail to provide relief. Analysis of stool samples of patients with GORD demonstrated different gut bacterial compositions to normal and rather resembled the one found in cancer. There is a clear need to improve the outcome of OG cancer. This could be achieved by identifying bacteria responsible for cancer development in gastric tissue, gastric content and saliva and potentially eliminate them hence avoid the development of cancer.

NCT ID: NCT03459339 Active, not recruiting - Barrett Esophagus Clinical Trials

Coordinating Center: Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy

Start date: April 4, 2017
Phase: N/A
Study type: Interventional

The goal of this research is to follow Barrett's Esophagus patients for 3 years using the tethered capsule endomicroscopy device with distal scanning and a compact imaging system in a multi-site clinical study.

NCT ID: NCT03316053 Active, not recruiting - Clinical trials for Barrett's Esophagus Without Dysplasia

Cell Marker Predictors in Barrett's Esophagus

Start date: November 15, 2017
Phase:
Study type: Observational

The purpose of this study is to analyze biopsied tissue samples for changes in cells and genes involved in Barrett's Esophagus.

NCT ID: NCT02994693 Active, not recruiting - Barrett Esophagus Clinical Trials

Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy

Start date: December 2016
Phase:
Study type: Observational

The goal of this research is to determine the natural history of Barrett's esophagus (BE) using tethered capsule endomicroscopy (TCE) in patients undergoing surveillance endoscopy.

NCT ID: NCT02864043 Active, not recruiting - Barrett's Esophagus Clinical Trials

Barrett's Dysplasia Detection Pilot Trial Using the NvisionVLE® Imaging System

DDP
Start date: September 2016
Phase: N/A
Study type: Interventional

The NvisionVLE® Dysplasia Detection Pilot Study is a prospective, non-randomized trial for participants who have a prior biopsy-confirmed diagnosis of BE with dysplasia and are scheduled to have an endoscopic evaluation of your esophagus for BE surveillance by a standard procedure called EGD (esophagogastroduodenoscopy) as well as an imaging procedure called VLE (volumetric laser endomicroscopy).

NCT ID: NCT02534233 Active, not recruiting - Esophageal Cancer Clinical Trials

Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium

ColdPlay2
Start date: April 2015
Phase: N/A
Study type: Interventional

Assess Cryoablation (CryoBalloon Ablation cryotherapy) for treatment of Dysplastic Barrett's Esophagus, Esophageal Squamous Dysplasia and early Esophageal Cancer. The cryoablation treatment will be offered as an alternative to standard ablation therapies such as Radiofrequency Ablation, Argon Plasma Coagulation and carbon dioxide Cryotherapy).