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Bacterial Keratitis clinical trials

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NCT ID: NCT06271772 Not yet recruiting - Bacterial Keratitis Clinical Trials

Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II

REAGIR II
Start date: April 30, 2024
Phase: Phase 3
Study type: Interventional

Rose Bengal Electromagnetic Activation with Green light for Infection Reduction II (REAGIR II) is a randomized, double-masked feasibility study. The purpose of this study is to determine differences in 6-month visual acuity between medical antimicrobial treatments alone versus antimicrobial treatment plus cross-linking with rose Bengal (RB-PDT). Patients presenting to one of the Aravind Eye Hospitals in India or to the Federal University of São Paulo ophthalmology clinic in Brazil with smear-positive and/or culture positive typical (I.e. non-Nocardia or Mycobacteria) bacterial corneal ulcers and moderate to severe vision loss, defined as Snellen visual acuity of 20/40 of worse, will be eligible for inclusion. Those who agree to participate will be randomized to one of two treatment groups: - Group 6, RB-PDT Plus Early Steroids: topical 0.5% moxifloxacin plus topical difluprednate 0.05% plus RB-PDT - Group 7, Sham RB-PDT Plus Early Steroids: topical 0.5% moxifloxacin plus topical difluprednate 0.05% plus sham RB-PDT

NCT ID: NCT05655689 Completed - Bacterial Keratitis Clinical Trials

The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study

Start date: December 31, 2021
Phase:
Study type: Observational

This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial therapies, with the main objective being to recommend the most effective empiric therapy. Microbial keratitis patients are attending the Cornea Outpatient Clinic at Alexandria Main University Hospital, Alexandria, Egypt.

NCT ID: NCT04213885 Recruiting - Bacterial Keratitis Clinical Trials

Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Position

Start date: May 4, 2020
Phase: Phase 2
Study type: Interventional

To determine whether the Peschke PXL-330 is safe and effective in the treatment of corneal thinning conditions.

NCT ID: NCT03918408 Recruiting - Bacterial Keratitis Clinical Trials

Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Conditions

Start date: September 1, 2019
Phase: Phase 1
Study type: Interventional

To determine whether the Peschke PXL-330 system is safe and effective in the treatment of corneal thinning conditions.

NCT ID: NCT03845374 Completed - Bacterial Keratitis Clinical Trials

Prospective, Randomized Multi-Center Study of Using the Hyper-CL™ Lens in Subjects Suffering From Bacterial Keratitis

Start date: March 13, 2019
Phase: N/A
Study type: Interventional

This study is a prospective, randomized, open-label, two arms, clinical study aim to evaluate the efficacy and safety of treatment with Hyper-CL™ lens + Antibiotics compared with treatment with Antibiotics only, in subjects with Bacterial keratitis. The design of the Hyper-CL™ lens increases contact time of the antibiotics on the cornea enabling increased bioavailability of the active drug.

NCT ID: NCT02497365 Completed - Bacterial Keratitis Clinical Trials

Besifloxacin in Bacterial Keratitis

Start date: September 2015
Phase: N/A
Study type: Interventional

This is a study comparing a new treatment for bacterial keratitis (also known as corneal ulcers) with the current standard of care. It is a randomized trial, and the investigators plan to test whether besifloxacin (a new antibiotic) in comparison to the current standard of treatment, fortified antibiotic drops (cefazolin and tobramycin).

NCT ID: NCT02088970 Terminated - Bacterial Keratitis Clinical Trials

Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study. (CXL)

CXL
Start date: September 2014
Phase: N/A
Study type: Interventional

The corneal collagen cross linking is currently used in the treatment of keratoconus but this procedure has also a sterilizing non-specific effect on bacteria and fungus. So the corneal cross linking in association with the antibiotic treatment could result in a reduction of the duration of epithelial complete healing of the cornea.

NCT ID: NCT02016989 Recruiting - Bacterial Keratitis Clinical Trials

Matrix Therapy And Bacterial Keratitis

CACICOL
Start date: November 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate efficiency of CACICOL20 for bacterial keratitis. It is a double blinded comparison of epithelial defect in two groups of patients randomized between CACICOL20 and physiological salt solution.

NCT ID: NCT01831206 Completed - Bacterial Keratitis Clinical Trials

Collagen Cross-linking in Infectious Keratitis Trial

Start date: March 2013
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.

NCT ID: NCT00707005 Completed - Bacterial Keratitis Clinical Trials

Antibiotic Susceptibility of Conjunctival Bacterial Isolates From Refractive Surgery Patients

Start date: June 2008
Phase: N/A
Study type: Observational

The purpose of this study is to determine the in vitro antibiotic susceptibility patterns of conjunctival bacterial flora isolated preoperatively from patients undergoing refractive surgery.