Clinical and Economic Impact of Interventions by a Clinical Pharmacist on Antibiotic Use on Surgical Wards

Bacterial Infections Clinical Trial

Official title:

Clinical and Economic Impact of Interventions by a Clinical Pharmacist on Antibiotic Use on Surgical Wards

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00431483
• Other study ID #: AW2007
• Status: Completed
• Phase: N/A
• First received: February 1, 2007
• Last updated: September 25, 2013
• Start date: February 2007
• Est. completion date: February 2008

Study information

• Verified date: September 2013
• Source: Ludwig-Maximilians - University of Munich
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to establish the impact of a pharmacist's recommendations regarding choice, dosing and duration of antibiotic therapy on quality and cost of antibiotic treatment on surgical wards.

Description:

Inappropriate or incorrect use of antibacterials exerts selection pressure on pathogens potentiating emergence of resistance, puts patients at risk for unnecessary adverse drug reactions and potentially prolongs the length of stay in hospital thus increasing healthcare costs.

In an effort to improve the quality of antibiotic drug therapy on surgical wards of a large university hospital, specific consulting by a clinical pharmacist was established.

The objective of this study is to assess the impact of pharmaceutical consulting on the quality and costs of antibiotic use in surgical wards.

Comparison:

Within a control period the current pattern of antibiotic use is monitored. During the intervention period, the impact of the interventions made by the clinical pharmacist on antibiotic use is examined. One ward serves as a parallel control group; no intervention is being made on this ward throughout this study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 779
• Est. completion date: February 2008
• Est. primary completion date: February 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• female and male patients receiving antibiotics for a proven or suspected infection on designated surgical wards

Exclusion Criteria:

• patients under 18

• patients unable or unwilling to consent to their data being evaluated

• patients receiving antibiotics perioperatively as prophylaxis

• patients receiving antibiotics for less than 48hrs

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Related Conditions & MeSH terms

• Bacterial Infections

Intervention

Behavioral:
• pharmaceutical consulting
to measure if information and advice by a pharmacist has an impact on quality and quantity of prescribed antibacterials

Locations

Country	Name	City	State
Germany	Luwig Maximilians University - Klinikum Grosshadern	Munich	Bavaria

Sponsors (1)

Lead Sponsor	Collaborator
Ludwig-Maximilians - University of Munich

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	overall duration of antibiotic therapy during study period		Feb 2008	No
Secondary	iv to oral switch	number of courses of iv antibiotics switched to oral antibiotics; duration of iv treatment	Feb 2008	No
Secondary	compliance of treatment with hospital formulary for antibiotic therapy		Feb 2008	No
Secondary	cost of antibiotic therapy		Feb 2008	No
Secondary	number and duration of therapy with antibiotics with redundant spectra		Feb 2008	No