Bacterial Infection Clinical Trial
Official title:
Exposure to NSAIDs (Non Steroidal Anti-Inflammatory Drugs) and Severity of Community-acquired Bacterial Infections
- NSAIDs are widely consumed, and some are currently available for self-medication with
indications 'Pain and Fever' (Cavalié, National Agency for Drug Safety (ANSM), 2014)
- There is no recommendation to limit their use in bacterial infections except for chicken
pox in children.
- To date, no study has highlighted the aggravating role of exposure to NSAIDs on
bacterial infections in adults, based on the usual septic severity Levy's score (SSS),
and mortality, but it delays adequate antibiotics (Legras, Critical Care, 2009)
- Community-acquired bacterial infections in adults exposed to NSAIDs are serious by their
spread (multiple locations), and suppurative character requiring frequent use of
invasive procedures such as surgery or drainage. The SSS does not reflect the
seriousness of these infections. They are frequently associated with use of ibuprofen
(63.4%), and self-medication practices (65.5%).
The main hypothesis is that NSAIDs exposure is associated with a specific severity of
community-acquired bacterial infection, marked by dissemination, suppurative complications or
even invasive procedures requirement.
Our objectives are also to:
- Describe what NSAID use terms are associated to the risk of serious bacterial
infections: molecule, dosage, duration of exposure, access (prescription or
self-medication), associated drugs.
- To determine what type (s) (s) of bacterial infection is worsened by exposure to NSAIDs.
- To determine if other risk factors contribute to severity of bacterial community
acquired infection
- To describe hospital costs associated to such severity of bacterial infection
n/a
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