Acute Kidney Injury Clinical Trial
Official title:
Elimination of Antibiotics During Citrate-anticoagulated Continuous-veno-venous-haemodialysis
Acute kidney injury (AKI) requiring renal replacement therapy is common in critically ill
patients. The major causes of AKI are severe sepsis and septic shock requiring effective
antibiotic treatment. Patients with sepsis on ICUs usually are haemodynamically instable so
that renal replacement therapy is applied using continuous techniques. In recent years, the
efficacy of renal replacement therapies has improved, namely by using regional citrate
anticoagulation which improves filter lifetime and filter patency. At present, the extent of
removal of antibiotic drugs using citrate-anticoagulated CVVHD in critically ill patients has
not been investigated thoroughly. Thus, the investigators want to investigate
1. whether and to what extent antibiotic drugs (piperacillin/tazobactam and
imipenem/cilastatin) are removed during citrate-anticoagulated CVVHD per se
2. whether filter patency during citrate-anticoagulated CVVD remains stable during a
treatment period of 72 h
n/a
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