Back Pain Clinical Trial
Official title:
Cells in the Lumbar Epidural Space of Patients With Low Back Pain and/or Radiculopathy
The investigators are doing this study to learn more about the cause of back pain with or without pain shooting down one or both legs. The investigators specifically want to know if cells that move into injured areas of the body are present in a space in the spine (epidural space) of patients with back pain and with or without shooting pain. The investigators will collect cells when patients are being treated, then examine the cells using a microscope. The investigators also will shine different colors of light into the epidural space to see if there is a correlation between how different colors of light are reflected and the types of cells present.
The objective of this study is to examine the cell population in the epidural space of
patients with low back pain +/- radiculopathy to determine if the cell population reveals
pathological processes sustaining the pain. Cells will be collected for microscopic
inspection and will be examined in situ during exposure to white and UV light. The overall
goal is to advance our knowledge about the etiology of low back pain +/- radiculopathy to
guide mechanistic based therapy.
The primary information sought is to determine if description of pathological processes based
upon direct observation with percutaneously placed epiduroscopes can be confirmed by
cytological analysis. the observations described include: 1) increased fibrosis from slight
to complete replacement of other tissue, or obliteration of the epidural space; 2) alteration
of color and/or appearance of epidural fat; 3) increased or decreased vascularity. The
overall description range from acute inflammatory changes to advanced fibrosis (scarring).
Specimens for cytological analysis will be obtained from different sites in the epidural
space by using commercially available cytology specimen collecting brushes and/or catheters.
These are inserted through the working channel of an epiduroscope into the lumbar epidural
space to aid treatment.
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