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A Phase 1/2 Study of CT120 in Patient With Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

B-cell Non-Hodgkin's Lymphoma Clinical Trial

Official title:
A Multicenter Phase I/II Clinical Study on Fully Human Anti-CD19/CD22 Dual Target Chimeric Antigen Receptor Autologous T Cell Injection (CT120) for the Treatment of Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

Clinical Trial Summary

This study is a single-armed, open-label,multicenter Phase 1/2 study to evaluate the safety and efficacy of CT120 in subjects with relapsed/refractory B-cell non-Hodgkin's lymphoma.

Clinical Trial Description

Leukapheresis procedure will be performed to manufacture CT120. Bridging therapy is allowed between PBMC collection and lymphodepletion. Lymphodepletion with fludarabine and cyclophosphamide was performed for three consecutive days. After 1-day rest, subjects will receive a single dose infusion of CT120. Subjects will be followed in the study for a minimum of 2 years after CT120 infusion. Long-term follow-up for lentiviral vector safety will be followed for up to 15 years after CT120 infusion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05091541
Study type Interventional
Source Nanjing IASO Biotherapeutics Co.,Ltd
Contact Ming Wu
Phone +86 0531-58287610
Email ming.wu@iasobio.com
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date October 20, 2021
Completion date October 20, 2039
View Details
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