Outcomes and Safety of Various Conduction System Pacing Methods

AV Block Clinical Trial

Official title: Registry of His Bundle, Bachmann Bundle and Left Bundle Branch Area Pacing for Various Pacing Indications

Status Recruiting

Clinical Trial Summary

The aim of this study is to evaluate safety and clinical outcomes after different pacing approaches of conduction system pacing in a prospective registry.

Clinical Trial Description

In comparison with right ventricular pacing-induced electromechanical dyssynchrony, conduction system pacing is providing physiological pacing via His-Purkinje activation. Current approaches include His bundle (HBP), left bundle branch area pacing (LBBAP), and Bachmann bundle pacing. In addition, HBP and LBBAP enable correction of underlying proximal bundle branch block, consequently improving the ventricular activation time and narrowing the QRS. Furthermore, atrial activation can be improved with direct Bachmann bundle stimulation. However, the data regarding long-term performance and safety of these physiological approaches in various clinical scenarios is scarce.

With this registry, the investigators would like to obtain real-world data regarding the feasibility and safety of this physiological pacing approaches in various pacing indications and their implementation in routine clinical practice.

Implant success rate, specific implant characteristics, procedural complications, electrical parameters and clinical outcomes will be analyzed at implantation, 1-3 months after inclusion and every 6 months thereafter. Minimal follow-up will be 2 years. ;

Related Conditions & MeSH terms

• Atrial Fibrillation
• Atrial Fibrillation Rapid
• AV Block
• Bundle-Branch Block

• NCT number: NCT04749836
• Study type: Observational [Patient Registry]
• Source: University Medical Centre Ljubljana
• Contact: David Žižek, Assist. Prof.
• Phone: +38615228534
• Email: david.zizek@kclj.si
• Status: Recruiting
• Start date: February 4, 2021
• Completion date: December 1, 2024