Cancer Clinical Trial
Official title:
Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood. Ancillary Study of the "Long-term Follow-up of Childhood Cancer Survivors in the Rhône-Alpes and Auvergne Regions of France" Study
The SALTO-SNA study is an ancillary study of the SALTO study (Suivi À Long Terme en
Oncologie des enfants guéris d'un cancer pédiatrique en régions Rhône-Alpes et Auvergne)
coordinated by Dr. Claire Berger, pediatric oncologist at the CHU, Saint Etienne. It aims at
re-examining, in their initial treatment center, all patients (a cohort of 495 patients
alive in 2011), diagnosed between 1987 and 1992, and cured of childhood cancer (except
leukemia) in the Rhône-Alpes and Auvergne regions.
The rationale for this study is based on the observation that although the survival rate of
childhood cancers has now reached 75%, complications of chemotherapy and radiotherapy are
high and greatly increase the risk of mortality in later years (estimated to be 14% in the
literature).
The morbidity risk of chemotherapy and radiotherapy can be quantified by assessing the
activity of the intrinsic cardiac autonomic regulation, which represents a powerful
predictor of cardiovascular morbidity to the individual.
For this purpose, analysis of the cardiac RR variability is a reliable, non-invasive and reproducible system that could be used in this population as a tool for early detection of cardiovascular dysfunction. ;
Observational Model: Cohort, Time Perspective: Prospective
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