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Autoimmune Disorders clinical trials

View clinical trials related to Autoimmune Disorders.

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NCT ID: NCT06434363 Not yet recruiting - Systemic Sclerosis Clinical Trials

Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders

Start date: November 30, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of Safety Lead-In is to confirm the safety of tafasitamab when given to patients with SSc, SLE, and LN. The goal of Phase 1 is to find the recommended dose of AD-PluReceptor-NK cells in combination with tafasitamab and lymphodepleting chemotherapy that can be given to patients with the disease. The goal of Phase 2 is to learn if the dose of AD-PluReceptor-NK cells found in Phase 1 in combination with tafasitamab and lymphodepleting chemotherapy can help to control the disease.

NCT ID: NCT05671757 Recruiting - Clinical trials for Autoimmune Disorders

Daratumumab in Primary Antiphospholipid Syndrome

DARE-APS
Start date: May 26, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to see if the study medication, daratumumab, is safe to treat individuals with Anti-Phospholipid Syndrome (APS). Three daratumumab dosing cohorts are planned with up to six participants in each dosing cohort with the potential to enroll an additional 4 subjects in the highest safe dose (HSD) cohort, for a total of up to 22 participants. The dosing cohorts are: 4 mg/kg, 8 mg/kg, and 16 mg/kg. Each cohort will receive intravenous (IV) administration of daratumumab according to the following schedule, for a total of 8 doses. The primary objective is to determine the safety of daratumumab in APS defined as Dose Limiting Toxicities (DLTs) occurring during the dose escalation phase.

NCT ID: NCT02972801 Recruiting - Cancer Clinical Trials

Testicular Tissue Cryopreservation for Fertility Preservation

Start date: January 2010
Phase:
Study type: Observational

Testicular tissue cryopreservation is an experimental procedure where a young boy's testicular tissue is retrieved and frozen. This technique is reserved for young male patients who are not yet producing mature sperm, with the ultimate goal that their tissue may be used in the future to restore fertility when experimental techniques emerge from the research pipeline.

NCT ID: NCT01489956 Terminated - Clinical trials for Autoimmune Disorders

A Study to Determine the Immunogenicity and Oral Tolerance to Keyhole Limpet Hemocyanin (KLH)

Start date: December 2011
Phase: Phase 0
Study type: Interventional

The purpose of this study is to test the oral tolerance of Keyhole Limpet Hemocyanin (KLH) and to determine if Immucothel by itself is strong enough to trigger the immune response. If not, Immucothel will be tested in combination with an adjuvant to determine if an adequate immune response can be seen.