Autism Access Link for Early Referral and Treatment

Autism Spectrum Disorder Clinical Trial

— Autism ALERT  

Official title:

Autism Access Link for Early Referral and Treatment

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04861740
• Other study ID #: 00001
• Status: Active, not recruiting
• Phase: N/A
• Start date: March 18, 2021
• Est. completion date: December 31, 2022

Study information

• Verified date: September 2022
• Source: Oregon Health and Science University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Autism Access Link for Early Referral and Treatment [ALERT], the intervention proposed in this application, is a novel state-wide referral and case management platform that PCPs can activate to ensure that a child with suspected ASD receives all necessary ASD diagnosis and treatment resources in a single referral, radically simplifying a complex diagnostic and treatment process. We hypothesize that Autism ALERT will have strong acceptability and high rates of use among primary care providers as well as among diverse low-income patients of children at risk for ASD, and that we will see higher rates of child ASD educational evaluations within six months, and shorter time between referral and ASD treatment, compared with our control.

Description:

Though significant research effort has focused on autism spectrum disorder (ASD) screening, less attention has been devoted to optimizing follow-up of children who are subsequently identified as at-risk. Despite increases in ASD screening rates, many children with ASD wait years between when autism is suspected in the primary care setting and when definitive diagnosis and treatment begin. Delayed and missed diagnoses are particularly problematic for low-income and racial/ethnic minority children in the US, who experience higher rates of these adverse outcomes. In this project, we propose to pilot test Autism Access Link to Early Referral and Treatment (Autism ALERT), a statewide monitoring and case management program to accelerate access to ASD diagnosis and treatment among children with suspected ASD the primary care setting. The system will reduce the time between identification of suspected ASD in the primary care setting and establishment of ASD diagnosis and treatment services, by reducing family barriers to care, decreasing primary care provider burdens, and simplifying referral processes. The program will be available to any Oregon child age 12-54 months, regardless of health system or payor type. Autism ALERT will become part of the Help Me Grow national network, which gives it potential for statewide and national spread. In this proposed research, we will pilot test Autism ALERT by comparing it to an existing ASD screening intervention in 6 Oregon primary care practices. Primary goals of this pilot project are to assess feasibility and acceptability of Autism ALERT for primary care providers and families, to test the mechanism of action of Autism ALERT, to pilot test efficacy in reducing time to autism diagnosis and treatment, and to test fidelity of protocol implementation. If successful, this project will be expanded into an implementation/effectiveness R01 in which the program will be tested throughout the state of Oregon. In the long term, this research will result in a sustainable, evidence-based statewide and ultimately national monitoring system children with suspected ASD.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 148
• Est. completion date: December 31, 2022
• Est. primary completion date: December 31, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 12 Months to 54 Months

Eligibility

Inclusion Criteria:

child's primary care provider suspects the child has ASD, child is patient at one of the study clinics, child age 12 to 54 months, family speaks English or Spanish, no prior ASD medical diagnosis or ASD diagnostic evaluation

Exclusion Criteria:

Previous diagnosis of ASD or prior diagnostic evaluation for ASD.

Related Conditions & MeSH terms

• Autism Spectrum Disorder
• Autistic Disorder

Intervention

Other:
• Autism ALERT
Autism Access Link for Early Referral and Treatment [ALERT], the intervention proposed in this application, is a novel state-wide referral and case management platform that PCPs can activate to ensure that a child with suspected ASD receives all necessary ASD diagnosis and treatment resources in a single referral, radically simplifying a complex diagnostic and treatment process.
• Screening Intervention
Autism screening intervention only.

Locations

Country	Name	City	State
United States	Ohsu Cdrc	Portland	Oregon

Sponsors (3)

Lead Sponsor	Collaborator
Oregon Health and Science University	Boston Medical Center, Providence Health & Services

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in satisfaction with Care Coordination in general and for autism in particular	2 separate provider survey measures	At enrollment and study end (~9 months after enrollment)
Primary	Change in Parent stress	Parent Survey - Parenting Stress Index	At enrollment and 6 months after enrollment
Primary	Change in Parenting stress	Questionnaire on Resources and stress - Short Form	At enrollment and 6 months after enrollment
Primary	Change in Family Empowerment	Parent Survey - Family Empowerment Scale, Family Subscale	At enrollment and 6 months after enrollment
Primary	Change in Family Centered and Coordinated Care	Parent Survey - Items from National Survey of Children's Health, Medical Home item set	At enrollment and 6 months after enrollment
Primary	Family Satisfaction with Program	Parent Survey items - Satisfaction with Interpersonal Relationship with Navigator (PSN-I), Client Satisfaction Questionnaire - 8	6 months after enrollment - Autism ALERT + Screening arm only
Primary	% referred to program who complete an ASD educational evaluation within 6 months	Administrative data - Oregon Early Intervention/Early Childhood Special Ed (EI/ECSE) database	6 months after enrollment
Primary	Time from EI/ECSE referral to ASD treatment in EI/ECSE, among children with ASD	Administrative data - Oregon EI/ECSE database	measured 9 months after enrollment
Primary	Family self-reported ASD knowledge	5-item survey measure	At enrollment and 9 months after enrollment
Primary	Change in provider self-efficacy about autism management	1-item survey measure	At enrollment and at study end (~9 months after enrollment)
Secondary	Change in provider autism paperwork burden	Provider survey item	At enrollment and at study end (~9 months after enrollment)
Secondary	Time from EI/ECSE referral to evaluation among children with ASD	Administrative data - Oregon EI/ECSE database	measured 9 months after enrollment
Secondary	Age of EI/ECSE educational determination, among children with ASD	Administrative data - Oregon EI/ECSE database	measured 9 months after enrollment
Secondary	% with ASD determination receiving ASD services 6 months after enrollment	Administrative data - Oregon EI/ECSE database	measured 9 months after enrollment
Secondary	monthly service hours among children with ASD 6 months after enrollment	Administrative data - Oregon EI/ECSE database	measured 9 months after enrollment
Secondary	age of ASD medical diagnosis among children on Medicaid	Administrative data - Medicaid claims	Measured 1 year after study enrollment
Secondary	% with ASD medical diagnosis receiving ASD therapy 6 months after enrollment, among children on Medicaid	Administrative data - Medicaid claims	Measured 1 year after study enrollment