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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04549506
Other study ID # YM102035
Secondary ID
Status Completed
Phase
First received
Last updated
Start date April 19, 2014
Est. completion date June 16, 2017

Study information

Verified date September 2020
Source National Yang Ming University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Empathy imbalance hypothesis suggests that individuals with autism Spectrum Disorder (ASD) should have a deficit of cognitive empathy and a surfeit of emotional empathy. Considering that inconsistent amygdala reactivity to emotional faces might be ascribed to aberrant attention in ASD, the investigators hypothesized to investigate if there would be an imbalance between conscious and nonconscious emotional processing. This fMRI study recruited 26 youths and young adults with autism spectrum disorder and 25 matched controls, and measured their amygdala reactivity and functional connectivity in response to conscious and nonconscious (backward masked) perception of threatening faces.

Keywords: Autism Spectrum Disorder; amygdala reactivity; emotional processing; fMRI


Recruitment information / eligibility

Status Completed
Enrollment 51
Est. completion date June 16, 2017
Est. primary completion date September 21, 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 13 Years to 40 Years
Eligibility Inclusion Criteria:

- Clinical diagnosis of severity of Autism-Spectrum Disorders

- IQ > 75

Exclusion Criteria:

- Neurological abnormalities,

- A history of epilepsy or seizures, head trauma a

- IQ <75

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Yawei Cheng

References & Publications (5)

Eimer M, Kiss M, Holmes A. Links between rapid ERP responses to fearful faces and conscious awareness. J Neuropsychol. 2008 Mar;2(Pt 1):165-81. doi: 10.1348/174866407X245411. — View Citation

Hall GB, Doyle KA, Goldberg J, West D, Szatmari P. Amygdala engagement in response to subthreshold presentations of anxious face stimuli in adults with autism spectrum disorders: preliminary insights. PLoS One. 2010 May 25;5(5):e10804. doi: 10.1371/journal.pone.0010804. — View Citation

Liddell BJ, Williams LM, Rathjen J, Shevrin H, Gordon E. A temporal dissociation of subliminal versus supraliminal fear perception: an event-related potential study. J Cogn Neurosci. 2004 Apr;16(3):479-86. — View Citation

Schumann CM, Amaral DG. Stereological analysis of amygdala neuron number in autism. J Neurosci. 2006 Jul 19;26(29):7674-9. — View Citation

Williams LM, Kemp AH, Felmingham K, Liddell BJ, Palmer DM, Bryant RA. Neural biases to covert and overt signals of fear: dissociation by trait anxiety and depression. J Cogn Neurosci. 2007 Oct;19(10):1595-608. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Age Age in years 1 minutes
Primary Anxiety scores State-Trait Anxiety Inventory (STAI) 10 minutes
Primary Severity of Austism-Spectrum Disorders Autism-Spectrum Quotient (AQ) 20 minutes
Primary Color identification task During fMRI scanning, subjects watched emotional faces and performed the color identification task, in which they were asked to judge the color of each face (pseudo-colored in either red, yellow, or blue) and to indicate the answer by a keypad button press. 10 minutes
Primary Detection task Immediately after fMRI scanning, participants underwent the detection task, during which they were shown all of the stimuli again and alerted of the presence of fearful faces. The subjects were administered a forced-choice test under the same presentation conditions as those during scanning and asked to indicate whether they observed a fearful face or not. 10 minutes
Primary fMRI response During fMRI scanning, subjects watched emotional faces and performed the color identification task, in which they were asked to judge the color of each face (pseudo-colored in either red, yellow, or blue) and to indicate the answer by a keypad button press. 10 minutes
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