Autism Spectrum Disorder Clinical Trial
Official title:
The Efficacy of EMDR in Youngsters With Autism: an Explorative Study
Rationale: Currently, for youngsters there is no treatment available that directly targets
the core symptoms of autism. EMDR is hypothesized to improve the core symptoms of ASD by
reducing the generally high stress levels experienced during social interactions, and
increasing the functional connectivity in neuronal networks associated with executive
functioning and limbic circuitry.
Objective: The primary objective of the study is to determine if EMDR reduces the core
symptoms of ASD and daily experienced stress in youngsters diagnosed with ASD.
Study design: Longitudinal multiple single case studies. Study population: Youngsters aged
12-21 years who are diagnosed with ASD and have a full-scale IQ of 80 or more (N=20).
Intervention: 10 weekly EMDR sessions.
Main study parameters/endpoints: The main endpoint of the study are autism symptoms, which
will be assessed using the Social Responsiveness Scale (SRS-A) and the Autism Diagnostic
Observation Schedule (ADOS 2). The SRS-A will be administered prior, during and after
treatment. The ADOS 2 will be administered prior to treatment and after treatment completion.
In addition, we will also administer the Trauma Symptom Investigation Form in Autism Spectrum
Disorders (TIF-ASD) questionnaire prior to, during, and after treatment. Furthermore, to
answer more fundamental questions concerning the working mechanism of EMDR in ASD, other
secondary outcome measures (i.e. PSS-10, AWMA-2) will be included.
Nature and extent of the burden and risks associated with participation, benefit and group
relatedness: Participants are expected to benefit from treatment. The risks associated with
study participation are considered negligible and the burden associated with participation is
estimated as low.
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