Autism Spectrum Disorder Clinical Trial
Official title:
Trial of Propranolol in Children and Youth With Autism Spectrum Disorder and Predictors of Response
The purpose of this study is to find out how the brain of people with autism is affected by
Propranolol. Propranolol is not FDA approved for the treatment of autism. Propranolol is FDA
approved for the treatment of heart conditions such as blood pressure
This research is being done because there are currently no drug treatment options for
language impairments and social difficulties often experienced by people with autism.
The specific aim of this study is to examine the effects of serial doses of propranolol on social interaction, and secondarily on language tasks, anxiety, adaptive behaviors, and global function in high functioning adults and adolescents with autism in a double-blinded, placebo-controlled trial. The investigators will also examine whether response to treatment can be predicted based upon markers of autonomic functioning, such as skin conductance, heart rate variability (HRV), and the pupillary light reflex (PLR), and whether anxiety can predict treatment response. The hypothesis is that social functioning and language abilities will benefit from serial doses of propranolol, and that those with the greatest degree of autonomic dysregulation, or the lowest functional connectivity, will demonstrate the greatest benefit from the drug. ;
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