Autism Spectrum Disorder Clinical Trial
Official title:
Early Detection of Autism Spectrum Disorder in Children
Rationale: Autism Spectrum Disorder (ASD) is defined by deficits in social interaction and
communication identified before the age of 3 years. Modified Checklist for Autism in
Toddlers (M-CHAT) is a sensitive tool for ASD screening in children 16-23 months. A limited
number of studies with a small number of patients have documented the developmental profile
of children with ASD during infancy. Retrospective evaluations of videotaped behavior of
children with ASD at 8 months and at 12 months identified early signs of ASD. A few studies
found early signs of ASD during infancy in siblings of autistic children. Data documenting
the age of onset and regression in ASD is controversial and limited. No large prospective
studies documented the specific developmental profile of children with ASD starting at 6
months of age. Defining a specific autistic pattern on a developmental screening test could
help identify infants at risk for ASD and improve their outcome through earlier diagnosis
and treatment. More recently, genetic tests have been shown to aid in early identification
of ASD which facilitates earlier intervention. Genetic testing among siblings of children
with autism can aid in identification of autism or other related disorders in the siblings.
PURPOSE: The purpose of this study is to learn about the early signs of autism in siblings
of children with autism spectrum disorders.
- The investigators will enroll siblings of children with ASD. Those siblings who
completed the Red Flags for Communication scale (RFC) at 6 months and/or at 12 months
and failed the RFC at 12 months will be given a genetic screening test.
- It is the investigators goal to define a specific autistic pattern on a developmental
screening test that could help identify sibling infants at risk for ASD and improve
their outcome through earlier diagnosis and treatment and to evaluate if the results of
the clinical screening test will correlate with the results of the genetic screening
test.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05207956 -
App for Strengthening Services In Specialized Therapeutic Support
|
N/A | |
Completed |
NCT03286621 -
Development of Eye-tracking Based Markers for Autism in Young Children
|
||
Completed |
NCT02608333 -
Efficiency of Early Intervention for Autism Spectrum Disorder
|
N/A | |
Recruiting |
NCT05935722 -
Evaluation of a Home-based Parenting Support Program: Parenting Young Children
|
N/A | |
Active, not recruiting |
NCT06259539 -
A YouTube Curriculum for Children With Autism and Obesity
|
N/A | |
Active, not recruiting |
NCT06303791 -
Digital-based Psychosocial Intervention for Parents of Children With Neurodevelopmental Disorders
|
N/A | |
Enrolling by invitation |
NCT05017779 -
A Hybrid Effectiveness-implementation Trial of a High School-based Executive Function Treatment for Autistic Youth
|
N/A | |
Completed |
NCT04772898 -
Effectiveness of a 6-week Hippotherapy Program in Children With Autism Spectrum Disorder
|
N/A | |
Recruiting |
NCT04987541 -
The Therapeutic Effect of TBS Stimulation on Emotion Regulation in Autism Spectrum Disorder
|
N/A | |
Completed |
NCT04308915 -
Mobile-based Games for Cognitive Training in Children With Neurodevelopmental Disorders
|
N/A | |
Completed |
NCT06038435 -
The Effect of Cognitive Orientation Approach on Daily Occupational Performance With Autism Spectrum Disorder
|
N/A | |
Terminated |
NCT04049981 -
Investigation of Mechanisms of Action in Superpower Glass
|
Phase 1/Phase 2 | |
Completed |
NCT03693313 -
The Effect of CrossFit Kids on Social Skills in Children With Autism Spectrum Disorder (CrossFit KAMP)
|
N/A | |
Recruiting |
NCT04107064 -
Achieving Steady Work Among Adults With Autism Through Specialized Employment Program
|
N/A | |
Recruiting |
NCT03812068 -
Parent-mediated Developmental Behavioral Intervention
|
N/A | |
Completed |
NCT03206996 -
Exposure Therapy for Auditory Sensitivity in Autism
|
N/A | |
Completed |
NCT02299700 -
Study to Evaluate the Janssen Autism Knowledge Engine in Children and Adults With Autism Spectrum Disorder
|
N/A | |
Completed |
NCT03422016 -
Electroretinogram in Autistic Spectrum Disorders
|
||
Active, not recruiting |
NCT03548779 -
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
|
N/A | |
Recruiting |
NCT05114538 -
Improving the Part C Early Intervention Service Delivery System for Children With ASD
|
N/A |