Attention Deficit Hyperactivity Disorder Clinical Trial
Official title:
Effects of Lisdexamfetamine on Cognitive Control and Reward Response in Adolescents and Young Adults With ADHD: Neural and Clinical Outcomes
The purpose of this study is to identify the effects of lisdexamfetamine (LDX) on the neural
and behavioral subcomponents of self-control, that is cognitive control and reward
functioning, in adolescents and young adults with attention-deficit/hyperactivity disorder.
The investigators hypothesize that LDX is associated with 1a) decreased task-independent
locus coeruleus (LC) activity; 1b) increased task-related activity in LC and the cognitive
control network; 2) increased LC connectivity with the cognitive control network and 3)
improved task performance and self-control. The investigators will test their hypotheses on
fMRI data with linear contrasts of voxel-wise maps of parameter estimates (in both univariate
and connectivity analyses).
The investigators will also assess change in brain activity with the LDX in the LC and
ventral tegmental areas (VTA) as we hypothesize that they are altered in ADHD and related to
cognitive control and self-control dysfunction in ADHD.
The investigators will use a repeated-measures, between-subject design to compare the effects
of oral once daily LDX in a double-blind placebo-controlled randomized trial (RCT) on neural
(fMRI) and behavioral correlates of cognitive control via a working memory and a reward -
delay discounting task in adolescents and young adults.
A new condition has been added which will use a within-subject comparison, cross-over design
between a single dose of LDX versus a single dose of placebo.
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