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Atrophy clinical trials

View clinical trials related to Atrophy.

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NCT ID: NCT05964634 Not yet recruiting - Myopia Clinical Trials

Effect of Peripapillary Atrophy to Diagnose Glaucoma in High Myopia

Start date: August 1, 2023
Phase:
Study type: Observational

This study intends to analyze the characteristics between peripapillary retinal nerve fiber layer thickness and peripapillary area in high myopia with or without glaucoma

NCT ID: NCT05963646 Active, not recruiting - Clinical trials for Age-Related Macular Degeneration

Optical Coherence Tomography and Microperimetry Biomarker Evaluation in Patients With Geographic Atrophy Study

OMEGA
Start date: March 16, 2021
Phase:
Study type: Observational

This study is a biomarker evaluation study in patients with geographic atrophy secondary to age-related macular degeneration (AMD). The study evaluates microperimetry (fundus-controlled perimetry) and optical coherence tomography imaging for assessing changes in retinal sensitivity and anatomy over time.

NCT ID: NCT05961332 Recruiting - Geographic Atrophy Clinical Trials

COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Geographic Atrophy

COCO-GA
Start date: October 6, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare measurements of geographic atrophy (GA) area between several types of imaging, in order to assess accuracy. The main question to answer is which imaging device provides measurements that are most similar to the standard of care device. Participants will be patients of a retina doctor at University Station Eye Clinic with geographic atrophy, and can expect to be in the study for 60-75 minutes.

NCT ID: NCT05957705 Completed - Dental Implants Clinical Trials

Maxillary Sinus Augmentation With Xenogeneic Bone Graft Associated or Not With Fibrin Rich in Platelets and Leukocytes Produced by Horizontal Centrifugation: A Randomized Clinical Trial.

Start date: March 17, 2021
Phase: N/A
Study type: Interventional

The objective of study is to evaluate the influence of the use of Platelet Rich Fibrin (PRF) from the patient's produced by a new horizontal centrifugation protocol associated with particulate xenogenous bone graft in the rehabilitation of atrophic maxillary sinus for early osseointegrated implants plancement. In a split-mouth model, twelve patients in need of rehabilitation with at least two bilateral implants in the regions of atrophic maxillary sinus will simultaneously undergo bone reconstruction using deproteinized particulate xenogenous bone (Bio-Oss Small®; Geistlich AG, Wolhusen , Switzerland). Randomly, one of the surgical sites of each patient will be reconstructed using the associated technique of solid PRF + Liquid PRF with the xenogen material, where at the end of the grafting procedure, both sites will be protected by a collagen membrane (Bio-Gide® Compressed; Geistlich AG, Wolhusen, Switzerland) positioned over the surgical access of the maxillary sinus. During the research, cone-beam computed tomography scans will be performed preoperatively, immediately after surgical procedure, 3 months after maxillary sinus reconstruction, after immediate implants placement and 12 months after functional load of the implants for comparative volume measurement of tissue gain and the maintenance of the grafted tissue. During the implant surgery, bilateral biopsies will be collected after 4 months of the regenerative surgical procedure during the early dental implants surgery by virtually guided surgery. The stability of the implants will be measured by means of resonance frequency analysis (ISQ) after the immediate postoperative period and 6 postoperative months as the clinical success rates of the implants after 12 months with functional load. The tissue samples will be used for histological, histomorphometric, immunohistochemistry and microtomographic analysis. All data obtained will be statistically analyzed.

NCT ID: NCT05953090 Recruiting - Vaginal Atrophy Clinical Trials

VALOR: Vaginal Atrophy & Long-term Observation of Recovery

VALOR
Start date: October 30, 2023
Phase: N/A
Study type: Interventional

Vulvovaginal skin conditions, namely vaginal atrophy, lichen sclerosus, lichen simplex chronicus and lichen planus affecting the female adult population will be treated with a novel gel dressing to test the short- and long-term safety and efficacy of the device.

NCT ID: NCT05949593 Recruiting - Geographic Atrophy Clinical Trials

Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy

PHOENIX
Start date: July 27, 2023
Phase: Phase 3
Study type: Interventional

This Phase 3, multicenter, double-masked, parallel-group, placebo-controlled, randomized, fixed-dose clinical study is designed to evaluate the efficacy and safety of tinlarebant (LBS-008) in subjects diagnosed with GA.

NCT ID: NCT05936437 Recruiting - Atrophic Scar Clinical Trials

Clinical Benefits and Safety of Combined Polynucleotides and Hyaluronic Acid - Newest - for Acne Scars Treatment

Start date: November 16, 2023
Phase: N/A
Study type: Interventional

This clinical study wants to evaluate the efficacy and safety of a medical device combining "Polynucleotide Highly Purified Technology" (PN-HPT™) and hyaluronic acid (Newest-Mastelli S.r.l) for treating moderate-to-severe atrophic post-acne scars.

NCT ID: NCT05931211 Not yet recruiting - Clinical trials for Spinal Muscular Atrophy

Motor Function and Activity of Daily Life in Spinal Muscular Atrophy

Start date: June 30, 2023
Phase:
Study type: Observational

This study will incorporate patients/ caregivers' perspectives to investigate the performance in daily activities of individuals with SMA and how it relates to their motor function abilities.

NCT ID: NCT05926219 Recruiting - Aging Clinical Trials

C-Protein in Fatigue and Aging

Start date: November 6, 2017
Phase: N/A
Study type: Interventional

This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.

NCT ID: NCT05923866 Recruiting - Clinical trials for Multiple System Atrophy (MSA)

A Phase 2 Study of ONO-2808 in Patients With Multiple System Atrophy

Start date: September 22, 2023
Phase: Phase 2
Study type: Interventional

This is a Phase 2, double-blind, parallel-group, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of multiple doses of ONO-2808 in patients with MSA. This is the first study of ONO-2808 in patients with MSA.