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Atrophic Scar clinical trials

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NCT ID: NCT06435884 Not yet recruiting - Atrophic Scar Clinical Trials

Long-Term Follow-up of Adult With Atorpphic Scars Treated With TRTP-101

Start date: September 2024
Phase:
Study type: Observational

CIC101-01-LT is a long-term follow-up study of subjects treated with TRTP-101 and will evaluate the long-term safety and efficacy of TRTP-101.

NCT ID: NCT06298591 Not yet recruiting - Atrophic Scar Clinical Trials

The Efficacy of Combination Therapy in Atrophic Scars

Start date: March 15, 2024
Phase: N/A
Study type: Interventional

There are more than 100 million patients who develop scar formation caused by various factors, such as post-inflammatory acne and trauma (1). They often have physical, aesthetic, psychological, and social barriers. Scar tissue is naturally a stage of wound healing. Abnormal wound healing produces a spectrum of scar tissue types such as atrophic, hypertrophic, and keloid scars (2). Atrophic scars are dermal depressions, which are commonly caused by the destruction of collagen following inflammatory process. This permanent disfiguring sequelae correlates with the duration of pathology, severity of lesion, and delay in therapy (3). Treatment of atrophic acne scars remains a therapeutic challenge, yet there is no standard option as the most effective treatment (4). A range of possible options has been investigated including surgical techniques (subcision, non-ablative laser treatment, resurfacing techniques (ablative laser treatment, dermabrasion), and injection or dermal fillers or fat, and a combination of two or more modalities (5). Ultrasound is a unique non-invasive and non-radiating medical imaging tool in the investigation of dermatological diseases by providing detailed anatomic and physiologic data of skin lesions and deeper soft tissue changes. Lesion size in three dimensions-lengths, width, and depth, morphology, the detailed anatomic information provided by sonography is useful to assessment of effect of different types of treatment modality to improve atrophic scar and avoid invasive assessment tools as punch biopsy for histopathological examination (6)

NCT ID: NCT05695807 Not yet recruiting - Atrophic Scar Clinical Trials

Carboxytherapy in the Treatment of Atrophic Scars

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

To evaluate the efficacy of CO2 versus fractional CO2 laser versus platelet rich plasma in treatment of atrophic scars using clinical assessment and ultrasonography