Left Bundle Branch Area Pacing in AVB Patients

Status Recruiting

Clinical Trial Summary

Right ventricular pacing (RVP) causes left ventricular mechanical dyssynchrony by inducing electrical interventricular and intraventricular dyssynchrony. His bundle pacing may restore the the atrioventricular, interventricular and intraventricular electrical synchronization, however, Increased pacing threshold might result in the early depletion of the pacemaker, and finally brought on pacemaker replacement, which was one of the major causes of device infection. Pacing the left bundle branch beyond the conduction block site might achieve a low and stable output and narrow QRSd. The investigators were prepared to consecutively include patients with atrioventricular block, divided into the left bundle branch area pacing(LBBAP) group and the conventional right ventricular pacing group. The electrophysiological characteristics of LBBAP and right ventricular pacing were compared with ECG characteristics. The left and right ventricular synchrony and left and right cardiac function were evaluated by 3D ultrasound, and the short-term and long-term safety and efficacy of LBBAP were evaluated.

Clinical Trial Description

This study is intended to be included in Fuwai hospital for admission to the atrioventricular block, with permanent pacemaker implant indications recommended by current guidelines. Patients were assessed for preoperative electrocardiogram, quality of life scores, cardiac function, and left and right ventricular synchrony. Patients were followed up by regular outpatients. The electrocardiogram, quality of life score, echocardiographic function, left and right ventricular synchrony, pacing parameters and pacing ratio were evaluated immediately after surgery, 3 months, 6 months, and 12 months after surgery. At the same time, the left bundle branch area pacing success rate, complications during intraoperative and postoperative follow-up were recorded. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03851315
Study type	Observational
Source	Fu Wai Hospital, Beijing, China
Contact
Status	Recruiting
Phase
Start date	May 1, 2018
Completion date	June 30, 2021

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06023784` - The Impact of LBBAP vs RVP on the Incidence of New-onset Atrial Fibrillation in Patients With Atrioventricular Block	N/A
Completed	`NCT01019213` - Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block	Phase 4
Completed	`NCT04884100` - enHEART - Exploring Full Content of Optical Signals to Enhance Cardiac Arrhythmia Screening	N/A
Recruiting	`NCT05774262` - Pacemaker Implantation Versus Cardioneuroablation for Functional Atrioventricular Block	N/A
Terminated	`NCT04093414` - Left Bundle Area Versus Selective His Bundle Pacing	N/A
Withdrawn	`NCT00559143` - Biventricular Alternative Pacing	Phase 4
Recruiting	`NCT04730921` - Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block)	N/A
Recruiting	`NCT05575557` - Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing Treatment	N/A
Completed	`NCT00187278` - Biopace Study: Biventricular Pacing for Atrioventricular Block to Prevent Cardiac Desynchronization	N/A
Recruiting	`NCT04595487` - LVSP vs RVP in Patients With AV Conduction Disorders	N/A
Completed	`NCT04269733` - Risk of Pacing-induced Cardiomyopathy
Completed	`NCT02282033` - Safety and Performance Study of the Moderato System	N/A
Completed	`NCT01922518` - Impact of Right Ventricular Pacing Determined by Electrocardiography	N/A
Recruiting	`NCT04624763` - Protection of Cardiac Function With Left Bundle Branch Pacing in Patients With Atrioventricular Block	N/A
Completed	`NCT03231826` - Arrhythmias in Post-Myocardial Infarction Patients
Not yet recruiting	`NCT04437901` - COVIDAR - Arrhythmias in COVID-19
Recruiting	`NCT01717469` - Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias	Phase 4
Completed	`NCT02154750` - AV Delay Optimization vs. Intrinsic Conduction in Pacemaker Patients With Long PR Intervals	N/A
Completed	`NCT02462941` - Analysis of Adenosine on Sinus and Atrioventricular Nodal Conduction in the Pediatric Transplanted Heart	Phase 1
Completed	`NCT00627328` - The Atrial High Rate Episodes in Pacemaker Patients	N/A