Atrioventricular Block Clinical Trial
Official title:
Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block
Conventional right ventricular (RV) apical pacing may result in asynchronous ventricular
contraction with delayed left ventricular activation, interventricular motion abnormalities,
and worsening of left ventricular ejection fraction. His pacing is preserving a synchronous
contraction and may prevent a decrease in left ventricular ejection fraction.
Hypothesis: His-pacing preserves left ventricular function and is a feasable alternative
compared to RV septal septal pacing in patients with AV-block.
Conventional right ventricular apical pacing may result in asynchronous ventricular
contraction with delayed left ventricular activation, interventricular motion abnormalities,
and worsening of left ventricular ejection fraction. His pacing is preserving a synchronous
contraction and may prevent a decrease in left ventricular ejection fraction.
The aims of our crossover, double-blinded, randomized study is to evaluate the feasibility
and long-term safety of permanent His pacing and to compare the effects on left ventricular
ejection fraction of permanent His pacing with those of conventional right septal
stimulation after 12 months treatment in patients with 2nd or 3rd degree AV-block.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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