Atrial Fibrillation Clinical Trial
Official title:
Intensive Molecular and Electropathological Characterization of patientS undergOing atriaL fibrillATion ablatION: a Multicenter Prospective Cohort Study
Rationale:
Although there are several individual factors which are known to influence the chances of
successful atrial fibrillation (AF) ablation, it remains a challenge to identify patients at
risk for ablation failure with satisfactory certainty.
Objectives:
To identify predictors of success of AF ablation including clinical factors, AF recurrence
patterns, anatomical and electrophysiological characteristics, circulating biomarkers and
individual genetic background.
Study design:
Prospective registry of patients undergoing AF ablation. Clinical characteristics and results
of routine tests are collected. In addition, the following (non-standard) tests are
performed: extended surface electrocardiogram (extECG), extended rhythm monitoring, biomarker
testing, genetic analysis, questionnaires. In subgroups of patients transesophageal
electrocardiogram (TE-ECG), epicardial electroanatomical mapping and/or left atrial appendage
(LAA) biopsy is performed.
Study population:
Patients aged 18 years and older with documented AF, scheduled for AF ablation.
Main study endpoints:
Ablation success after 12 and 24 months, defined as freedom from any episode of documented
atrial arrhythmia after the blanking period.
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