Atrial Fibrillation New Onset Clinical Trial
Official title:
The Effect of Silymarin on the Prevention of Atrial Fibrillation After Coronary Artery Bypass Graft Surgery
The study is a prospective, randomized, controlled trial to assess the effects of silymarin on the occurrence of postoperative atrial fibrillation after coronary artery bypass graft surgery.
Status | Recruiting |
Enrollment | 160 |
Est. completion date | July 1, 2025 |
Est. primary completion date | January 1, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility | Inclusion Criteria: - scheduled for elective CABG surgery using cardiopulmonary bypass - first cardiac surgery - left ventricular ejection fraction > 35% - less than moderate mitral regurgitation Exclusion Criteria: - preoperative atrial fibrillation - previous history of interventionally treated arrhythmias - end-stage renal disease requiring hemodialysis - chronic inflammatory and neoplastic diseases |
Country | Name | City | State |
---|---|---|---|
Serbia | Institute of Cardiovascular Diseases of Vojvodina | Sremska Kamenica |
Lead Sponsor | Collaborator |
---|---|
University of Novi Sad |
Serbia,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of participants with postoperative atrial fibrillation | Occurrence of postoperative atrial fibrillation lasting at least 30 s on a rhythm strip or 12-lead ECG | 4 days | |
Secondary | ICU length of stay | Total duration of stay in the intensive care unit | 30 days | |
Secondary | Hospital length of stay | Total duration of stay in hospital | 30 days | |
Secondary | Postoperative complications | Occurrence of postoperative complications including pericardial effusion, stroke, and in-hospital death | 30 days | |
Secondary | Blood concentration of white blood cells | Postoperative values of white blood cells | 4 days | |
Secondary | Blood concentration of C-reactive protein | Postoperative values of C-reactive protein | 4 days |
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