Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes

Athlete Clinical Trial

Official title:

Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes From Different Sports: Cross-sectional, Interventional, and Follow-up Studies

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03321110
• Other study ID #: MOST106-2410-H-030-065
• Status: Completed
• Phase: N/A
• Start date: December 1, 2017
• Est. completion date: July 31, 2019

Study information

• Verified date: March 2020
• Source: Chung Shan Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day).

Description:

The long-term high-amount and -intensity exercise training could cause oxidative damage, muscle impairment, inflammation and exercise fatigue to athletes easily. Such above conditions will affect the exercise performances and health of athletes. The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day). Eventually, these results of this study can provide the information for the known to improve the oxidative stress, anti-oxidation and inflammation internal to the bodies of athletes for various competitions. As a consequence, the athletic performances can be further enhanced.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 43
• Est. completion date: July 31, 2019
• Est. primary completion date: July 31, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Athletes (soccer and taekwondo players)

Exclusion Criteria:

• Antioxidant vitamins users

• Statins or Aspirin therapy.

Related Conditions & MeSH terms

• Athlete
• Fatigue

Intervention

Other:
• Placebo
Placebo (dextrin)

Dietary Supplement:
• Coenzyme Q10
150 mg or 300 mg

Locations

Country	Name	City	State
Taiwan	Chung Shan Medical University	Taichung

Sponsors (1)

Lead Sponsor	Collaborator
Chung Shan Medical University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	malondialdehyde (MDA)	MDA (micromol/L) will measure by thiobarbituric acid reacting substance.	12 weeks
Secondary	Antioxidant capacity	Total antioxidant capacity (TAC) was measured by a Trolox equivalent antioxidant capacity assay in serum and erythrocytes.	12 weeks
Secondary	high sensitivity C-reactive protein (hs-CRP)	hs-CRP will measure by immunoturbidimetry.	12 weeks
Secondary	creatine kinase (CK)	serum CK will measure by enzymatic method.	12 weeks
Secondary	Lactate dehydrogenase (LDH)	serum LDH will measure by enzymatic method.	12 weeks
Secondary	one-repetition maximum (1-RM)	1RM measurements will report in kilograms for data analysis.	12 weeks
Secondary	Glucose	mmol/L	12 weeks
Secondary	HbA1C	HbA1C will measure by an automated glycated hemoglobin analyzer	12 weeks
Secondary	Insulin	insulin will measure by an automated chemistry analyzer	12 weeks