Clinical Benefit of Using Molecular Profiling to Determine an

Status Active, not recruiting

Clinical Trial Summary

This is a 2 strata pilot trial within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). The study will use a new treatment approach based on each patient's tumor gene expression, whole-exome sequencing (WES), targeted panel profile (UCSF 500 gene panel), and RNA-Seq. The current study will test the efficacy of such an approach in children with High-grade gliomas HGG.

Clinical Trial Description

For children with High-grade gliomas (HGG) including HGG presenting within the midline structures of the brain and spine, outcome remains poor and the majority of children die from this disease. The current study will use a new treatment approach based on each patient's tumor gene expression, whole-exome sequencing (WES), targeted panel profile (UCSF 500 gene panel), and RNA-Seq. This treatment strategy has shown promising results in adult patients with solid tumors and is currently being explored in children with DIPG, neuroblastoma and other solid tumors. The current study will test the efficacy of such an approach in children with HGG for which outcomes remain dismal. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03739372
Study type	Interventional
Source	University of California, San Francisco
Contact
Status	Active, not recruiting
Phase	N/A
Start date	November 28, 2018
Completion date	January 1, 2027

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Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma — PNOC008

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms