Asthma Clinical Trial - Role of Toilet Bronchoscopy in RICU

Status Recruiting

Clinical Trial Summary

Toilet bronchoscopy is a potentially therapeutic intervention to aspirate retained secretions within the endotracheal tube and airways and revert atelectasis. Aspiration of airway secretions is the most common indication to perform a therapeutic bronchoscopy in the intensive care unit (ICU) . Toilet bronchoscopy is particularly beneficial when retained secretions are visible during the procedure and when air-bronchograms are not present at the chest radiograph. It is also beneficial when there is an indication to reverse lobar atelectasis, rather than simply to remove accumulated mucus. Toilet bronchoscopy is used in lobar and complete lung collapse in mechanically ventilated patients who fail to respond to treatments such as physiotherapy or recruitment manoeuvres. The success rates (defined as radiographic improvement on chest X-ray [CXR] or an improved PaO2/PAO2 ratio) in the ICU patient population had. Patients with acute hypoxaemic respiratory failure may already be on non-invasive ventilation (NIV), or require NIV preemptively for Fiberoptic Bronchoscopy (FB). These patients should be considered high risk for requiring intubation post-procedure; therefore, Fiberoptic Bronchoscopy should be performed by an experienced operator in a setting allowing facilities to safely secure the airways. NIV with early therapeutic FB rather than mechanical ventilation can help avoid intubation and reduce tracheostomy rate. Hospital mortality, duration of ventilation, and hospital stay remain similar

Clinical Trial Description

Aim Of Work To study the value of toilet bronchoscopy in 1. Mechanical ventilated patients with chest disease and copious secretion. 2. Mechanical ventilated patients diagnosed to have atelectasis radiologically. 3. Patients on non-invasive ventilation with chest diseases and copious secretion 4. Compare Different types of mucolytics during toilet bronchoscopy in mechanically ventilated patients. 5. Compare Different types of sedations during toilet bronchoscopy in mechanically ventilated patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04798118
Study type	Interventional
Source	Assiut University
Contact	Shaimaa A Mohammed, MD
Phone	01016599093
Email	drshimaalimohammed@gmail.com
Status	Recruiting
Phase	N/A
Start date	April 1, 2022
Completion date	December 2023

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.