Asthma Clinical Trial
Official title:
A Comparison of Two Nebulisers for Performing Sputum Induction to Assess Airway Inflammation
Sputum induction is considered a relatively non-invasive, reliable procedure, which can be
utilised to characterise the inflammatory profile of the airways.
However, the procedure can be slightly uncomfortable for patients. This study aims to assess
the differences in participants' tolerability of sputum induction, by comparing two different
nebulisers when performing the procedure.
This is a single centre, crossover study to compare the use of two nebulisers in the sputum
induction procedure. 54 participants with stable asthma or COPD will be recruited and will
attend 2 visits, at least 48 hours apart. Differences in the quality and quantity of samples
and the time taken to produce a sample will be described. The main purpose is to explore the
optimum device to perform the procedure, whilst protecting the safety of participants and
maximising their comfort.
If participants are unable to produce a sputum sample after completion of the induction
procedure, physiotherapy techniques may be performed. This is an exploratory objective to
establish whether these techniques may help in the event of unsuccessful procedures.
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