Protection Against Allergy: Study in Rural Environment - Part IV

Asthma Clinical Trial

— PATURE IV  

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02929277
• Other study ID #: R/2012/47
• Status: Completed
• Phase: N/A
• Start date: October 2013
• Est. completion date: May 6, 2015

Study information

• Verified date: October 2016
• Source: Centre Hospitalier Universitaire de Besancon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

PASTURE is a birth cohort of children born to farm and non-farm women from rural areas across Europe. Five study centres Austria, Germany, Switzerland, France and Finland enrolled 1133 children (farmers in about half of the children) to study the origins of asthma and atopy and to develop potential preventive strategies.

Previous results show a protective effect of farm exposure on allergic risk by livestock contacts and microbial exposures and by raw cow milk consumption in early age.

PASTURE Part IV is the 10-year follow up of this birth cohort. The primary objective is to characterize the allergic phenotype between 6 and 10 years old (asthma and allergic rhinitis) and to explain how early age exposures and particularly milk products consumption contribute in the process of allergic illness in childhood. A focus on the characterization of the protective biologically active components in raw milk and identification of immunological mechanisms are involved.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 131
• Est. completion date: May 6, 2015
• Est. primary completion date: May 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 10 Years to 11 Years

Eligibility

Inclusion Criteria:

• PATURE IV is a birth cohort. All children enrolled at the beginning and who still agree to participate will be included at 10-year follow-up.

Exclusion Criteria:

Related Conditions & MeSH terms

• Asthma
• Atopy

Intervention

Other:
• blood sampling, skin prick tests, assesment of atopic dermatitis, questionnaires

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Besancon

References & Publications (2)

Chauveau A, Dalphin ML, Kaulek V, Roduit C, Pugin A, von Mutius E, Vuitton DA, Dalphin JC. Disagreement between Skin Prick Tests and Specific IgE in Early Childhood. Int Arch Allergy Immunol. 2016;170(2):69-74. doi: 10.1159/000446776. Epub 2016 Jul 26. — View Citation

Chauveau A, Dalphin ML, Mauny F, Kaulek V, Schmausser-Hechfellner E, Renz H, Riedler J, Pekkanen J, Karvonen AM, Lauener R, Roduit C, Vuitton DA, von Mutius E, Dalphin JC; PASTURE Study Group. Skin prick tests and specific IgE in 10-year-old children: Agr — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Asthma		10 years old
Primary	Rhinitis		10 years old
Primary	Atopic Dermatitis		10 years old
Primary	Food Allergy		10 years old
Primary	Skin prick tests		10 years old
Primary	Specific Immunoglobulin E (IgEs)		10 years old
Primary	Blood cytokine profiles		10 years old