Animal Allergy in Korean Veterinary Researcher

Asthma Clinical Trial

Official title:

Sensitization to Animal Allergens and Allergic Symptoms During Exposure to Animal Allergens in Korean Veterinary Researcher

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02866864
• Other study ID #: GachonUGilMC
• Status: Completed
• Phase: N/A
• First received: July 31, 2016
• Last updated: March 2, 2017
• Start date: August 24, 2016
• Est. completion date: September 1, 2016

Study information

• Verified date: March 2017
• Source: Gachon University Gil Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The investigators will evaluate sensitization to animal allergens and allergic symptom during contacting animal allergens in Korean veterinary researchers who attend their annual conference.

The investigators will compare sensitization to animal allergen and other clinical and occupational factors between subjects who suffer from allergic symptom during contacting animal and those who do not.

Description:

The investigators will visit annual conference of Korean veterinary researchers.

After informed consent, Korean veterinary researchers who attend their conference and agree to enrollment into this study will be asked to respond to questionnaires regarding their gender, age, underlying allergic diseases, family history of allergic diseases, occupation and it's duration, contact animal and contact duration. Subjects will also be requested to report allergic symptom, causal animal and situation of contact including veterinary service, animal experiment, pet ownership, and ingestion if subjects suffer from allergic symptom when subjects contact animal.

Then, subjects will also be asked to undergo skin prick test for animal allergens including chicken feather and ten mammal epithelia as well as cow's milk, and hen's egg, four fish flesh and seven animal meats.

subjects will be divided into two group, subjects who suffer from allergic symptom during contacting animal and those who do not. Between two groups, sensitization to animal allergens as well as other demographic and occupational factors including gender, age, underlying allergic diseases, family history of allergic diseases, occupation and it's duration, contact animal and contact duration will be compared.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 135
• Est. completion date: September 1, 2016
• Est. primary completion date: August 26, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 19 Years and older

Eligibility

Inclusion Criteria:

• Veterinary researchers attending their annual conference

Exclusion Criteria:

• Veterinary researchers who receive medication including antihistamine (H1 and H2 blocker), systemic glucocorticosteroid which can effect on the result of skin prick test

• Veterinary researchers who do not want to participate in this study

Related Conditions & MeSH terms

• Asthma
• Dermatitis
• Dermatitis, Atopic
• Rhinitis
• Rhinitis, Allergic
• Urticaria

Intervention

Other:
• Animal allergy +
Allergic symptom occurs when subject contact animal
• Animal allergy -
Allergic symptom does not occur when subject contact animal

Locations

Country	Name	City	State
Korea, Republic of	Gachon University Gil Medical Center	Incheon

Sponsors (1)

Lead Sponsor	Collaborator
Gachon University Gil Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (10)

Blair A, Hayes HM Jr. Cancer and other causes of death among U.S. veterinarians, 1966-1977. Int J Cancer. 1980 Feb 15;25(2):181-5. — View Citation

Elbers AR, Blaauw PJ, de Vries M, van Gulick PJ, Smithuis OL, Gerrits RP, Tielen MJ. Veterinary practice and occupational health. An epidemiological study of several professional groups of Dutch veterinarians. I. General physical examination and prevalence of allergy, lung function disorders, and bronchial hyperreactivity. Vet Q. 1996 Dec;18(4):127-31. — View Citation

Krakowiak A, Wiszniewska M, Krawczyk P, Szulc B, Wittczak T, Walusiak J, Palczynski C. Risk factors associated with airway allergic diseases from exposure to laboratory animal allergens among veterinarians. Int Arch Occup Environ Health. 2007 May;80(6):46 — View Citation

Lutsky I, Baum GL, Teichtahl H, Mazar A, Aizer F, Bar-Sela S. Occupational respiratory disease in veterinarians. Ann Allergy. 1985 Aug;55(2):153-6. — View Citation

Moghtaderi M, Farjadian S, Abbaszadeh Hasiri M. Animal allergen sensitization in veterinarians and laboratory animal workers. Occup Med (Lond). 2014 Oct;64(7):516-20. doi: 10.1093/occmed/kqu097. — View Citation

Park YB, Mo EK, Lee JY, Kim JH, Kim CH, Hyun IG, Choi JH. Association between pet ownership and the sensitization to pet allergens in adults with various allergic diseases. Allergy Asthma Immunol Res. 2013 Sep;5(5):295-300. doi: 10.4168/aair.2013.5.5.295. — View Citation

Samadi S, Spithoven J, Jamshidifard AR, Berends BR, Lipman L, Heederik DJ, Wouters IM. Allergy among veterinary medicine students in The Netherlands. Occup Environ Med. 2012 Jan;69(1):48-55. doi: 10.1136/oem.2010.064089. — View Citation

Samadi S, Wouters IM, Heederik DJ. A review of bio-aerosol exposures and associated health effects in veterinary practice. Ann Agric Environ Med. 2013;20(2):206-21. Review. — View Citation

Susitaival P, Kirk JH, Schenker MB. Atopic symptoms among California veterinarians. Am J Ind Med. 2003 Aug;44(2):166-71. — View Citation

Will LA, Nassif EG, Engen RL, Patterson RA, Zimmerman D. Allergy and pulmonary impairment in Iowa veterinarians. N Engl Reg Allergy Proc. 1987 May-Jun;8(3):173-7. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Skin reactivity to animal allergen in skin prick test	Mean diameter of wheal for animal allergen in skin prick test	on the day of survey (day 1)
Secondary	Underlying allergic disease	Underlying allergic disease including allergic rhinitis, asthma, atopic dermatitis, urticaria, food and drug allergy	on the day of survey (day 1)
Secondary	Family history of allergic disease	Family history of allergic disease including allergic rhinitis, asthma, atopic dermatitis, urticaria, food and drug allergy	on the day of survey (day 1)
Secondary	Occupation	Type of occupation including veterinary service and veterinary experiment	on the day of survey (day 1)
Secondary	Duration of occupation	Duration of occupation (year)	on the day of survey (day 1)
Secondary	Contact animal	Kinds of animals that subjects contact	on the day of survey (day 1)
Secondary	Contact time	Duration of animal contact (hour/day)	on the day of survey (day 1)
Secondary	Causal animal	Animal that provokes allergic symptom when subject contact it	on the day of survey (day 1)
Secondary	Contact situation	Situation including veterinary service, veterinary research, ingestion and pet ownership in which subject contact animal that provokes allergic symptom	on the day of survey (day 1)
Secondary	Allergic symptom during contacting animal	Allergic symptom including itchy eyes, nose and skin, rhinorrhea, sneezing, nasal congestion, postnasal drip, dyspnea, wheezing, cough, sputum, chest pain or discomfort, urticaria, rash, and angioedema when subject contact animal	on the day of survey (day 1)