Asthma Clinical Trial
Official title:
A Randomized Trial Comparing Metered Dose Inhalers and Breath Actuated Nebulizers
This study is determines if metered dose inhalers are as effective as breath actuated nebulizers for the treatment of mild to moderate asthma exacerbations in pediatric patients presenting to the emergency department. Half of the participating patients received albuterol via the metered dose inhaler whereas the other half received albuterol via the breath actuated nebulizer.
Albuterol administered via metered dose inhalers with spacers are more effective than small
volume nebulizers in the treatment of acute pediatric asthma exacerbations. There is also
supporting data that the breath actuated nebulizers are also more effective than small volume
nebulizers. The effectiveness of breath actuated nebulization compared to MDI for treating
asthma exacerbations is less well defined.
Metered dose inhalers with spacers are more readily available to the general population, are
easily transportable and do not require a power source. Demonstrating equal effectiveness of
albuterol delivery systems for treatment of acute pediatric asthma exacerbations would enable
physicians to confidently utilize clinical encounters as opportunities to educate families on
management of asthma exacerbations using their home appliance.
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