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NCT02749565 Clinical Trial

The Role of Endothelium A and EGFR Receptor in Fibrocytes From Asthma With Obstructive Sleep Apnea

Asthma Clinical Trial

Official title:
he Role of Endothelium A and EGFR Receptor in Fibrocytes From Asthma With Obstructive Sleep Apnea

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT02749565
Other study ID # 102-5744A3
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 2015
Est. completion date April 2022

Study information
Verified date November 2018
Source Chang Gung Memorial Hospital
Contact TSAI-YU WANG, MD
Email wang5531@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The investigators will compare the circulating fibrocyte proportion in asthmatic patients with obstructive sleep apnea (OSA) and not with OSA In addition, the investigators will compare the expression of epidermal growth factor receptor (EGFR), endothelin A receptor (ETAR) and connective tissue growth factor (CTGF) The association of those factors and annual decline of forced expiratory volume in 1 second (FEV1) will be performed

Description:

Asthma is characterized by airflow obstruction, chronic airway inflammation and remodeling. The investigators' report has shown directly the relationship between fibrocytes, and chronic airflow obstruction with rapid decline in FEV1 in asthma. Asthma concomitant of obstructive sleep apnea (OSA) may appear intermittent hypoxia and result in the frequent attack of asthma symptoms. In animal model, hypoxia may increase the circulating fibrocytes, thus play a role in pulmonary hypertension. The investigators' published paper also showed that an increased expression of EGFR, ETAR and Vascular endothelial growth factor receptor (VEGFR) in circulating fibrocytes in chronic obstructive asthmatics. It is unknown whether circulating fibrocytes from asthma with OSA have the higher expression of EGFR, connective tissue growth factor receptor, VEGFR and ETAR compared to asthma without OSA. The investigators are also interested in whether proliferation and differentiation of fibrocytes are different between asthmatics with or without concomitant of OSA. The investigators will study the correlation between the percentage of circulating fibrocytes and the oxygen desaturation index (ODI) and severity of sleep apnea to clarify the role of hypoxia, which contributing to chronic asthma.

Recruitment information / eligibility
Status Recruiting
Enrollment 60
Est. completion date April 2022
Est. primary completion date April 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years to 100 Years
Eligibility Inclusion Criteria:

- clinical diagnosis of asthma

Exclusion Criteria:

- chronic obstructive pulmonary disease (COPD)

- bronchiectasis

- cystic fibrosis

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan Chang Gung Memorial Hospital Taipei

Sponsors (2)
Lead Sponsor Collaborator
Chang Gung Memorial Hospital Ministry of Science and Technology, Taiwan

Country where clinical trial is conducted

Taiwan, 

Outcome
Type Measure Description Time frame Safety issue
Primary circulating fibrocyte proportion between asthmatic patient with OSA and without OSA baseline
Secondary the change of circulating fibrocyte proportion in asthmatic patients with OSA baseline
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