Asthma Clinical Trial
Official title:
Effects of Ultra-long Acting Bronchodilator Therapy Assessed by Impulse Oscillometry in Smoking Asthmatics Taking Inhaled Corticosteroids
Single centre, open-label, random order, cross-over trial, recruited over a period of
approximately 2 years. Sufficient participants enrolled to complete 16 adults. Withdrawn
subjects may be replaced.
This clinical trial will assess the effects of ultra-long acting bronchodilator therapy in
smoking asthmatics taking inhaled corticosteroids. This will be via a pulmonary function test
called impulse oscillometry.
Cigarette smoking in asthma is associated with poorer asthma control and a higher frequency
of asthma attacks. Despite this, smoking cessation rates are very low due to the highly
addictive nature of tobacco smoking. Asthma in smokers is particularly challenging to manage
because it is resistant to the beneficial effects of inhaled corticosteroids, the main
treatment for asthma.
Unfortunately, there is no guideline consensus regarding how to best manage asthmatics who
smoke. Research studies in asthma tend to exclude smokers because of concerns about
recruiting patients with chronic obstructive pulmonary disease (COPD). Hence, there is an
unmet need for research studies in asthmatics who are unable to stop smoking.
In view of the above, we propose to assess the effects of two different types of
bronchodilators (inhalers which help open up the airways), in asthmatics who continue to
smoke.
Participants will receive both of the following drugs for 2-4 weeks in random order, with a
2-3 week washout period in between:
Olodaterol which is a new long-acting bronchodilator. Olodaterol combined with tiotropium
(dual bronchodilators). We wish to compare these inhalers using a sensitive pulmonary
function test called impulse oscillometry.
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