Asthma Clinical Trial
Official title:
Assessment of a Device Used for Measuring the Rheological Parameters of Human Sputum.
This is a proof of concept study. The aim of this study is to assess a device measuring
rheological properties of human sputum of four populations :
- 10 patients with Broncho Chronic Obstructive Pulmonary Disease (COPD)
- 10 patients with asthma
- 10 patients with cystic fibrosis
- 10 healthy volunteers.
This study includes two visits to 48 hours apart.
During the first visit :
- Patients with COPD or cystic fibrosis will have a spontaneous expectoration
- Then all study participants will have an induced expectoration with hypertonic salin
solution (4.5%).
During the second visit :
- Patients with COPD or cystic fibrosis will have a spontaneous expectoration
- Then, patients with COPD, asthma and healthy volunteers will have an induced
expectoration with hypertonic salin solution (4.5%). Patients with cystic fibrosis will
have a spontaneous expectoration 1 hour after an RhDNAse nebulization.
A control spirometry will be perform before each expectoration and during induced
expectoration if necessary.
All sputum sample collected will be homogenized and then divided into two equal volumes in
order to perform two separate rheological measurements of 15 minutes.
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