Asthma Clinical Trial
Official title:
Effect of Vitamin D Repletion on Asthma Exacerbation
The study aim is in two phases. First phase: to evaluate the influence of vitamin D deficiency on asthma severity, degree of airway obstruction and frequency of asthma exacerbations. Second phase: to evaluate if in patients with vitamin D deficiency (25-OH vitamin D levels below 20 ng/ml), vitamin D supplementation decreases the number of disease exacerbations.
The first phase of the study consisted of a cross-sectional examination of a cohort of 119
asthmatic patients, who had at least one year regular follow-up in our respiratory clinic,
and were not receiving any vitamin D supplementation.
In the second phase patients with vitamin D deficiency (25-OH D values below 20 ng/ml), were
recruited in a one year longitudinal study, during which they received vitamin D
supplementation. The study started and ended in late autumn-winter season when, at our
latitude, sun exposure is lowest. Symptoms, spirometry and number of exacerbations were
recorded during both study phases.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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